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ACTG announces the addition of two monoclonal antibodies to ACTIV-2 outpatient treatment study for COVID-19


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Los Angeles, Calif. - The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, today announced the addition of two monoclonal antibodies, BMS-986414 and BMS-986413, to the COVID-19 outpatient treatment study, ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial. BMS-986414 and BMS-986413 will be administered as subcutaneous injections (shots) given at one visit. ACTIV-2 includes both phase 2 and phase 3 evaluations of multiple investigational agents for treating early COVID-19 in a single trial. For information about enrolling in the trial, please visit the study website.
Given that prevention and treatment will continue to be an important part of ending the COVID-19 pandemic, it is key that we identify and develop a variety of treatment options, said ACTG Chair Judith Currier, M.D., M.Sc., University of California, Los Angeles (UCLA). ACTIV-2 is studying a number of different therapeutic approaches, including infusions, ....

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Cilia in fallopian tube essential for egg but not embryo transport


Cilia in fallopian tube essential for egg but not embryo transport
Motile cilia are needed to transport ovulated eggs in the fallopian tube, according to new research.
The study, published in the Proceedings of the National Academy of Sciences (PNAS), used mice lacking motile cilia, which are little hairs found in the fallopian tube, to show that they are essential for transporting eggs from the ovary to the uterus. The study further clarified that smooth muscle, which was also thought to move eggs in the fallopian tube, is instead more important for moving sperm and embryos.
We are very excited about solving this longstanding mystery, said Dr Wei Yan, an investigator at the Lundquist Institute in Torrance, California, who led the study. It is now clear that both motile cilia and smooth muscle participate in the transport function, and motile cilia are required for egg pickup, whereas smooth muscle contraction is more important for sperm and embryo transport. ....

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Lundquist investigators in global study expanding genomic research of different ancestries


Credit: The Lundquist Institute
LOS ANGELES (May 31, 2021) Today The Lundquist Institute announced that its investigators contributed data from several studies, including data on Hispanics, African-Americans and East Asians, to the international MAGIC collaboration, composed of more than 400 global academics, who conducted a genome-wide association meta-analysis led by the University of Exeter. Now published in
Nature Genetics, their findings demonstrate that expanding research into different ancestries yields more and better results, as well as ultimately benefitting global patient care. Up to now nearly 87 percent of genomic research of this type has been conducted in Europeans.
We are very excited about contributing to this global study, said Dr. Jerome I. Rotter, Investigator and Director of the Institute for Translational Genomics and Population Sciences at The Lundquist Institute and Professor of Pediatrics and Human Genetics at the Geffen School of Medicin ....

United States , Cassandra Spracklen , Jeromei Rotter , Max Benavidez , Ji Chen , Geffen School Of Medicine , University Of Massachusetts , Institute For Translational Genomics , Lundquist Institute , University Of Exeter , Population Sciences , East Asians , Nature Genetics , Translational Genomics , Human Genetics , Geffen School , East Asian , South Asian , Saharan African , Assistant Professor , Trans Ancestral Genomic Architecture , Glycemic Traits , Population Biology , Health Care , Medicine Health , Health Care Systems Services ,