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Damaged mitochondria activate autoimmunity suggests genome study


Damaged mitochondria activate autoimmunity suggests genome study
Appeared in BioNews 1095
Accumulation of defective mitochondria in cells may contribute to autoimmune conditions, such as Sjögren s syndrome, according to a recent study.
Researchers showed that mice lacking the
IRGM1gene showed similar autoimmune symptoms to patients with Sjögren s syndrome because they were not able to properly recycle their mitochondria. This left damaged parts of mitochondria in the cells, triggering an immune response against them.
Many autoimmune diseases exhibit increased type 1 interferon, said Dr Michael Fessler, senior author and head of the immunity, inflammation, and disease laboratory at the US National Institute of Environmental Health Sciences (NIEHS) in North Carolina. Our studies show how mitochondrial DNA that is not removed activates the immune system in mice and how it may happen in humans. ....

North Carolina , United States , Rosie Morley , Michael Fessler , Prashant Rai , Us National Institute Of Environmental Health Sciences , Environmental Health Sciences , வடக்கு கரோலினா , ஒன்றுபட்டது மாநிலங்களில் , ரோஸி மோர்லி , மைக்கேல் பெஸ்சிலேற் , பிரஷண்ட் ராய் , எங்களுக்கு தேசிய நிறுவனம் ஆஃப் சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் , சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் ,

FRAME | Why our March Interior of the Month is a masterclass in mixed-use space


The Frame Awards jury has crowned a hostel-cum-library in rural China as the winning project in the latest round of Interiors of the Month.
Our March Interior of the Month winner combines two unexpected typologies: a capsule hostel and community library. To get there, one must make their way through the deep forests of Tonglu, in China’s Zhejiang province. There they’ll encounter the village of Qinglongwu, where the Atelier Tao+C-designed space is located. The firm renovated a traditional old house constructed from wood and mud walls, transforming it into a 10-room lodge centred by an expansive library and bookstore open to the public. Submitted in the category of Hotel, the Capsule Hostel and Bookstore Qinglongwu achieved a total mark of 8.81, celebrated very highly in the creativity criteria, the end score of which was a remarkable 9.47. ....

Al Iskandariyah , Al Qahirah , Loreak Mendian , Shao Feng , Jose Luis Lopez , Venelin Kokalov , Rosie Morley , Tom Ross , Martijn Hoogendijk , Shengliang Su , Office Group , Frame Awards , March Interior , Capsule Hostel , Bookstore Qinglongwu , Fender Katsikakis , San Sebasti , Breathe Architecture , Best Use , Co Living Complex , Costa Mahindroo Architects , ஷா ஃபெங் , ஜோசே லூயிஸ் லோபஸ் , ரோஸி மோர்லி , டோம் ரோஸ் , அலுவலகம் குழு ,

Crying human tear glands grown from stem cells

Crying human tear glands grown from stem cells
bionews.org.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bionews.org.uk Daily Mail and Mail on Sunday newspapers.

Rachel Kalmann , Hans Clevers , Rosie Morley , University Medical Centre , Hubrecht Institute , Professor Hans Clever , Cell Stem , Professor Hans Clevers , Professor Clevers , ரோஸி மோர்லி , பல்கலைக்கழகம் மருத்துவ மையம் , செல் தண்டு ,

FRAME | Who is our March jury? Here are the 15 industry experts on the team


Anne-Laure Pingreoun, design curator and founder of Alter-Projects and Alternative-Thinkers
Anne-Lauren Pingreoun is a design curator and founder of Alter-Projects, a new generation multidisciplinary company curating special projects which build unique stories and social experiences for designers, brands, and property developers, and Alternative-Thinkers, an online platform where creative practitioners set the framework and are then connected to funding. Her clients include the likes of the LVMH Group, London Design Festival, UK Government, Art Basel and more.
Caro Lundin, co-founder and creative director of ARC Club
As the creative director of London co-working brand ARC Club, Caro Lundin oversees every detail of the product and its use – from build-through to merchandise and marketing. Based between Stockholm and London, Lundin attended the Bartlett School of Architecture and formerly worked at Crab Studio and Sundae Design Studio, which she co-founded with a speci ....

Kuala Lumpur , United Arab Emirates , United States , France General , United Kingdom , British Columbia , City Of , Noord Holland , New South Wales , Liu Kai , Esra Lemmens , Anne Laure Pingreoun , Oxford Brookes , Caro Lundin , Waad El Hadidy , David Chenery , Kai Liu , Shao Feng , Anne Lauren Pingreoun , Roel Slabbers , Ettore Sottsass , Sergio Mannino , Venelin Kokalov , Rosie Morley , Joey Rademakers , Martijn Hoogendijk ,