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Damaged mitochondria activate autoimmunity suggests genome study

Damaged mitochondria activate autoimmunity suggests genome study
Appeared in BioNews 1095
Accumulation of defective mitochondria in cells may contribute to autoimmune conditions, such as Sjögren s syndrome, according to a recent study.
Researchers showed that mice lacking the
IRGM1gene showed similar autoimmune symptoms to patients with Sjögren s syndrome because they were not able to properly recycle their mitochondria. This left damaged parts of mitochondria in the cells, triggering an immune response against them.
Many autoimmune diseases exhibit increased type 1 interferon, said Dr Michael Fessler, senior author and head of the immunity, inflammation, and disease laboratory at the US National Institute of Environmental Health Sciences (NIEHS) in North Carolina. Our studies show how mitochondrial DNA that is not removed activates the immune system in mice and how it may happen in humans. ....

North Carolina , United States , Rosie Morley , Michael Fessler , Prashant Rai , Us National Institute Of Environmental Health Sciences , Environmental Health Sciences , வடக்கு கரோலினா , ஒன்றுபட்டது மாநிலங்களில் , ரோஸி மோர்லி , மைக்கேல் பெஸ்சிலேற் , பிரஷண்ட் ராய் , எங்களுக்கு தேசிய நிறுவனம் ஆஃப் சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் , சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் ,

Adrian Politowski's L.A.-Based Align Joins 'Little Nicholas' as Co-Financier (EXCLUSIVE)

Adrian Politowski s L.A.-Based Align Joins Little Nicholas as Co-Financier (EXCLUSIVE)
Elsa Keslassy, provided by
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Adrian Politowski’s Align, the L.A. based production and finance company, has come on board to co-finance “Little Nicholas,” a hand-drawn animated feature directed by Amandine Fredon and Benjamin Massoubre.
The feature is being produced by Aton Soumache at ON Kids & Family (“The Little Prince”), a Mediawan Group company, and Lilian Eche and Christel Henon at Bidibul Productions. Charades, the banner behind the Oscar-nominated “Mirai,” is handling international and domestic sales.
More from Variety
Fredon and Massoubre previously worked on “Ariol” and “I Lost My Body,” respectively. Created by the author Rene Goscinny and the New Yorker illustrator Jean-Jacques Sempe, “Le Petit Nicolas” follows the adventures of a mischievous boy and his schoolmates, teacher and parents in Paris in the 1960s. ....

New York , United States , France General , New Yorker , Little Prince , Jean Jacques Sempe , Aton Soumache , Anne Goscinny , Benjamin Massoubre , Adrian Politowski , Rene Goscinny , Le Petit Nicolas , Mediawan Group , Based Align Joins , Little Nichola , Amandine Fredon , Lilian Eche , Christel Henon , Lost My Body , Michel Fessler , Michael Caine , Co Financier , La Based Align Joins , On Kids 38 , Bidibul Productions , Cryptic Hungarian Portmanteau Drama Lets No Light In Berlin Player ,

US B-1B Lancer debuts at Aero India 2021 > Air Mobility Command > Article Display

US B-1B Lancer debuts at Aero India 2021 > Air Mobility Command > Article Display
af.mil - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from af.mil Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , Ellsworth Air Force Base , South Dakota , Republic Of India , Rajnath Singh , Michael Fessler , Mark Weatherington , Indian Air Force , Bomber Task , Indian Air , Global Strike Operations Center , Ellsworth Air Force , Aero India , Yelahanka Air Force Station , Eighth Air Force , Joint Global Strike Operations Center , United State , Task Forces , Expeditionary Bomb Squadron , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , தெற்கு டகோட்டா , குடியரசு ஆஃப் இந்தியா , ராஜ்நாத் சிங் , மைக்கேல் பெஸ்சிலேற் ,

B-1 Bomber pilot impressed with Tejas counterpart

He has been flying a B-1 for about 17 years ....

Michael Fessler , Indian Air , Us Air , Light Combat Aircraft , Aero India , மைக்கேல் பெஸ்சிலேற் , இந்தியன் அேக , எங்களுக்கு அேக , ஒளி போர் வான்கலம் , வான ஊர்தி இந்தியா ,