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NIMH » Past Research


Psychosocial Stress, Environmental Enrichment, and Hippocampal Neurogenesis
A naturalistic model of chronic stress that mimics depressive conditions in humans is psychosocial stress, achieved in mice by creating a housing condition in which an aggressive dominant mouse and a subordinate mouse live together separated by a perforated barrier. The persistent conflict results in socially defeated subordinate mice that show behavioral signs of increased anxiety, helplessness, anhedonia, and inappropriate social interaction, assessed in validated behavioral tests. We showed that environmental enrichment housing in large cages with tubes, toys, and a running wheel following social defeat restores the normal behavior of the subordinate mice. We found that adult neurogenesis is required for the restorative effects. We also found that the environmental enrichment is protective when it is given prior to the psychosocial stress, and these effects are neurogenesis-dependent and require ....

New York , United States , Brain Research , Environmental Enrichment , Volume Transmission , Novel Mechanisms , Raven Press , Potential Role , Fragilex Mental Retardation , Adult Synaptic , Comp Neurol , Brain Res , Opioid Receptor Localization , Academic Press , Therapeutic Targets , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , மூளை ஆராய்ச்சி , சுற்றுச்சூழல் செறிவூட்டல் , ரேவந் ப்ரெஸ் , பொடெந்ஶியல் பங்கு , மூளை ரெஸ் , சிகிச்சை இலக்குகள் ,