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NIMH » Past Research

Psychosocial Stress, Environmental Enrichment, and Hippocampal Neurogenesis
A naturalistic model of chronic stress that mimics depressive conditions in humans is psychosocial stress, achieved in mice by creating a housing condition in which an aggressive dominant mouse and a subordinate mouse live together separated by a perforated barrier. The persistent conflict results in socially defeated subordinate mice that show behavioral signs of increased anxiety, helplessness, anhedonia, and inappropriate social interaction, assessed in validated behavioral tests. We showed that environmental enrichment housing in large cages with tubes, toys, and a running wheel following social defeat restores the normal behavior of the subordinate mice. We found that adult neurogenesis is required for the restorative effects. We also found that the environmental enrichment is protective when it is given prior to the psychosocial stress, and these effects are neurogenesis-dependent and require ....

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What the Pandemic Is Doing to Our Brains

The Atlantic
We have been doing this so long, we’re forgetting how to be normal.
Peter Marlow / Magnum
I first became aware that I was losing my mind in late December. It was a Friday night, the start of my 40-somethingth pandemic weekend: Hours and hours with no work to distract me, and outside temperatures prohibitive of anything other than staying in. I couldn’t for the life of me figure out how to fill the time. “What did I used to … do on weekends?” I asked my boyfriend, like a soap-opera amnesiac. He couldn’t really remember either. ....

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