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Researchers reveal process behind harmful glial cell change in motor neurone disease


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Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurone disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behaviour. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

United Kingdom , City Of , Oliver Ziff , Rickie Patani , University College London , King College London , Queen Square Institute Of Neurology , Nucleic Acids Research , National Hospital For Neurology , Imperial College London , Cancer Research United Kingdom , Research Council , Francis Crick Institute , Square Institute , National Hospital , Medical Research Council , Cell Biology , Medicine Health , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , ஆலிவர் ஸிஃப் , ரிக்கி படானி , பல்கலைக்கழகம் கல்லூரி லண்டன் , கிங் கல்லூரி லண்டன் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , தேசிய மருத்துவமனை க்கு நரம்பியல் ,

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis


Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis
Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease. The findings could help develop new treatments for many neurological diseases with the same change, including Parkinson s and Alzheimer s.
When the nervous system is injured, diseased or infected, star-shaped cells, called astrocytes, undergo reactive changes in their behavior. Whilst some of these reactive astrocytes become protective, others become harmful and damage surrounding motor neurons.
Reactive astrocytes are observed in various neurodegenerative diseases including ALS, but there is a lack of understanding about what causes astrocytes to undergo this change. ....

Oliver Ziff , Rickie Patani , Emily Henderson , National Hospital For Neurology , Queen Square Institute Of Neurology , Group Leader , Nucleic Acids Research , Francis Crick Institute , Senior Study Author , Queen Square Institute , Consultant Neurologist , National Hospital , Square Institute , Motor Neurone Disease , Amyotrophic Lateral Sclerosis , Genetic Information , Motor Neurons , Nervous System , Neurodegenerative Diseases , Stem Cells , ஆலிவர் ஸிஃப் , ரிக்கி படானி , எமிலி ஹென்டர்சன் , தேசிய மருத்துவமனை க்கு நரம்பியல் , ராணி சதுரம் நிறுவனம் ஆஃப் நரம்பியல் , குழு தலைவர் ,