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Normally harmless cell molecule triggers neuron death

Credit: Wanli Liu
A vital intermediate in normal cell metabolism is also, in the right context, a trigger for cell death, according to a new study from Wanli Liu and Yonghui Zhang of Tsinghua University, and Yong Zhang of Peking University in Beijing, publishing 26th April 2021 in the open access journal PLOS biology. The discovery may contribute to a better understanding of the damage caused by stroke, and may offer a new drug target to reduce that damage.
Farnesyl pyrophosphate (FPP) is an intermediate in the mevalonate pathway, a series of biochemical reactions in every cell that contributes to protein synthesis, energy production, and construction of cell membranes. During a search for regulators of immune cell function, the authors unexpectedly discovered that FPP, when present at high concentrations outside of cells, caused rapid and extensive death of cells. FPP carries both a highly charged phosphate head and a long hydrophobic hydrocarbon tail, and by altering eac ....

United States , Yonghui Zhang , Yong Zhang , Wanli Liu , Tsinghua Center , National Natural Science Foundation Of China , China Postdoctoral Science Foundation , Innovation Center , National Institutes Of Health , Uaeu Tsinghua Asian Universities Alliance , Natural Science Foundation , Municipal Science Technology Commission , Life Sciences , Institute For Immunology , National Natural Science Foundation , Tsinghua University , National Key Rd Program Of China , Peking University , Tsinghua Asian Universities Alliance Joint Grant , Beijing Natural Science Foundation , Beijing Advanced Innovation Center , Beijing Municipal Science , Technology Commission , National Institutes , Postdoctoral Fellowship , Peking Tsinghua Center ,

Diseño centrado en el ser humano: Revitalizando la ribera histórica de Shanghai

Diseño centrado en el ser humano: Revitalizando la ribera histórica de Shanghai
plataformaarquitectura.cl - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from plataformaarquitectura.cl Daily Mail and Mail on Sunday newspapers.

Yong Zhang , Liu Yuyang , Fred Kent , Museum Moma , Bund Finance Center , Programme Of Improvement , Favourite Long Museum , Shanghai Moma Museum Waterfront Park For Yiyu , Long Museum , Shanghai Moma Museum , Centre Shanghai Lujiazui , Design Of Shanghai Moma Museum Waterfront Park , Ribera Shanghai , Minsheng Wharf , Image Fangfang Tian , Scarlett Hmong Led , Santiago Baraya April , Binjiang Avenue , Lujiazui Shanghai Pudong , Avenue Binjiang , Boriginal Design , Yang Pu Riverside , Image Yong Zhang , Image Changheng Zhan Section , Yangpu Riverside Public , Image Changheng ,

Thornburg Grows Institutional Distribution Team

Thornburg Grows Institutional Distribution Team
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SANTA FE, N.M., March 3, 2021 /PRNewswire/ Thornburg Investment Management ( Thornburg ), a global investment firm that oversees $47 billion in assets
1, today announced the addition of two new members to the institutional distribution team to develop relationships with asset owners and consultants in the U.S. and Canada.
Jennifer Pittman joins Thornburg as a regional director for the Eastern United States and Christopher Kuhl joins the team as a senior regional associate, supporting institutional clients in the Eastern portions of the United States and Canada. Both Ms. Pittman and Mr. Kuhl report to Anne Lundberg, head of institutional distribution at Thornburg. ....

New Mexico , United States , Hong Kong , City Of , United Kingdom , Chris Elsmark , Frances Dalessio , Jennifer Pittman , Caroline Hui , Michael Corrao , Andrew Gu , Ben Smiley , Segal Rogerscasey , Phillip Bennett , Carter Sims , Christopher Kuhl , Yong Zhang , Janne Lundberg , Jens Bjorheim , William Blair , Global Communications , Marquette Associates , Intersec Research , Dartmouth College , Fiera Capital Corporation , University Of Illinois ,

推少子化專法 綠委批國發會保守籲勇於任事 - 政治

推少子化專法綠委批國發會保守籲勇於任事 - 政治
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T Ai Pei , Yang Wenshan , Qiu Zhiwei , Yong Zhang , Progressive Party , China Progressive Party , Institute Research , Central Institute Agency , Development Committee , Yong Chinese Culture University Labor , Law Green Committee , Executive Yuan , Associate Professor , Force Road , Prime Minister Ann , Basic Law , டி ஐ பேய் , யோங் ஜாங் , ப்ரோக்ரெஸிவ் கட்சி , நிறுவனம் ஆராய்ச்சி , வளர்ச்சி குழு , நிர்வாகி யுவான் , இணை ப்ரொஃபெஸர் , படை சாலை , அடிப்படை சட்டம் ,

文化局藝術亮點紅點文旅獨家公開展出張雍最新創作

文化局藝術亮點紅點文旅獨家公開展出張雍最新創作
sina.com.tw - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sina.com.tw Daily Mail and Mail on Sunday newspapers.

Yong Zhang , Department Of Cultural Affairs , Cultural Affairs , Figure Department , Taichung City , National Road , யோங் ஜாங் , துறை ஆஃப் கலாச்சார வாழ்க்கைத்தொழில்கள் , கலாச்சார வாழ்க்கைத்தொழில்கள் , தேசிய சாலை ,