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Functional autoantibody in COVID-19 contributes to the 'firestorm' of blood clots and inflammation


Functional autoantibody in COVID-19 contributes to the firestorm of blood clots and inflammation
Researchers at Michigan Medicine have discovered yet another functional autoantibody in COVID-19 patients that contributes to the disease s development and the firestorm of blood clots and inflammation it induces.
A growing body of studies suggests COVID-19 emulates many aspects of systemic autoimmune disorders, including the release of a flurry of overactive immune cells that produce toxic webs of proteins and DNA called neutrophil extracellular traps, or NETs.
For this study, the team analyzed serum from over 300 hospitalized COVID patients, searching for a novel autoantibody that shields the toxic NETs from being destroyed and produces a lasting noxious effect in a patient s body. ....

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Introducing NIH's Newest Lasker Scholars | NIH Intramural Research Program


The Voice and
America’s Got Talent are any indication, there are many extremely talented people out there who could become huge successes if presented with the right opportunity. This is no less the case in science, with thousands of extremely bright individuals quietly toiling away in their mentors’ labs as they await the chance to establish research programs of their own.
Fortunately, initiatives like the NIH’s Lasker Clinical Research Scholars Program exist to boost promising young researchers on to the next stage of their careers. Every year, the Lasker program allows a small group of early stage physician-scientists to establish their own labs at the NIH and carry out independent clinical research there for at least five years. ....

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