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Specific gene may play a causal role in heart disease independent of cholesterol levels


Specific gene may play a causal role in heart disease independent of cholesterol levels
High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.
But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.
The study appears March 24 in the journal
Science Translational Medicine.
Studying mice and genetic data from people, the researchers found that the gene called SVEP1 makes a protein that drives the development of plaque in the arteries. In mice, animals missing one copy of SVEP1 had less plaque in the arteries than mice with both copies. The researchers also selectively reduced the protein in the arterial walls of mice, ....

Jareds Elenbaas , Nathano Stitziel , Hyuk Jung , Emily Henderson , Washington University Office Of Technology Management , Washington University School Of Medicine , Washington University School , Science Translational , Associate Professor , In Hyuk Jung , Washington University , Technology Management , Blood Pressure , Cardiovascular Disease , Coronary Artery Disease , Heart Attack , High Blood Pressure , High Cholesterol , யுக் ஜங் , எமிலி ஹென்டர்சன் , வாஷிங்டன் பல்கலைக்கழகம் அலுவலகம் ஆஃப் தொழில்நுட்பம் மேலாண்மை , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , அறிவியல் மொழிபெயர்ப்பு , இணை ப்ரொஃபெஸர் , இல் யுக் ஜங் ,