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Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients


Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients
Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers. Now, researchers working in the U.S., Germany and China have shown how chemotherapy drugs called thiopurines can lead to mutations that set patients up for relapse. The work appears today in the journal
Nature Cancer.
The research provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy and are not always present at diagnosis.
The findings offer a paradigm shift in understanding how drug resistance develops. The results also suggest possible treatment strategies for ALL patients who relapse, including screening to identify those who should avoid additional thiopurine treatment. ....

Yao Chen , Chao Tang , Fan Yang , Li Xia , Bing Zhou , Benshang Li , Pandurang Kolekar , Huiying Sun , Hongzhuan Chen , Cornelia Eckert , Emily Henderson , Houshun Fang , Tianyi Wang , Jeffery Klco , Xiaotu Ma , Omkar Pathak , Jiaoyang Cai , Jinghui Zhang , Renate Kirschner Schwabe , Samuel Brady , Xiaomeng Li , Malwine Barz , Caiwen Duan , Shuhong Shen , Yu Liu , Shanghai Jiao Tong University School Of Medicine ,

在暴雨中合力"撑伞"——社会各界驰援河南_石家庄新闻网


极端强降雨袭来,国家救援队伍星夜驰援,紧急预拨救灾资金,处置水库险情,民间自救、互救,社会各界捐款捐物……国家强力保障、社会各界力量支援的暖心善举,已经在暴雨中汇成一股合力。
7省1800名消防救援指战员驰援河南
一方有难,八方支援。针对河南省郑州市连降暴雨引发的险情,消防救援队伍跨区域增援预案启动,应急管理部连夜调派河北、山西、江苏、安徽、江西、山东、湖北7省消防救援水上救援专业队伍驰援河南防汛抢险救灾。
河南省消防救援总队根据汛情发展,于7月20日提升战备等级,紧急调派焦作、许昌、漯河、新乡、商丘、驻马店6个支队开展人员搜救、排水排涝、转移群众等工作。
截至21日14时,消防救援队伍出动指战员2.37万人次、舟艇3121艘次,共营救遇险被困群众6459人,疏散群众1.53万人。
财政� ....

Jin Ji Yu , Zhengzhou Jiaozuo Xinxiang , Yao Chen , Technology Museum , Zhengzhou Library Science , Point Of Service Transportation , Henan Shijiazhuang News Guangming Daily , Henan Province , Zhengzhou Midwest , Starry Night , Zhengzhou City , Country Start , Henan Province Zhengzhou City , Cross Region , Province Fire , Henan Province Fire , Jiaozuo Xuchang Luohe Xinxiang Shangqiu Zhumadian , Water Conservancy , Chang Village Reservoir , Zhengzhou Chang Village Reservoir , Reservoir Guo , Dam Singapore , Guo Reservoir , South North Water Transfer Project , Province City , Place Zhengzhou ,

在暴雨中合力"撑伞"——社会各界驰援河南-中工民生-中工网


极端强降雨袭来,国家救援队伍星夜驰援,紧急预拨救灾资金,处置水库险情,民间自救、互救,社会各界捐款捐物……国家强力保障、社会各界力量支援的暖心善举,已经在暴雨中汇成一股合力。
7省1800名消防救援指战员驰援河南
一方有难,八方支援。针对河南省郑州市连降暴雨引发的险情,消防救援队伍跨区域增援预案启动,应急管理部连夜调派河北、山西、江苏、安徽、江西、山东、湖北7省消防救援水上救援专业队伍驰援河南防汛抢险救灾。
河南省消防救援总队根据汛情发展,于7月20日提升战备等级,紧急调派焦作、许昌、漯河、新乡、商丘、驻马店6个支队开展人员搜救、排水排涝、转移群众等工作。
截至21日14时,消防救援队伍出动指战员2.37万人次、舟艇3121艘次,共营救遇险被困群众6459人,疏散群众1.53万人。
财政� ....

Jin Ji Yu , Zhengzhou Jiaozuo Xinxiang , Yao Chen , Technology Museum , Zhengzhou Library Science , Point Of Service Transportation , Henan Guangming Daily , Henan Province , Zhengzhou Midwest , Starry Night , Zhengzhou City , Country Start , Henan Province Zhengzhou City , Cross Region , Province Fire , Henan Province Fire , Jiaozuo Xuchang Luohe Xinxiang Shangqiu Zhumadian , Water Conservancy , Chang Village Reservoir , Zhengzhou Chang Village Reservoir , Reservoir Guo , Dam Singapore , Guo Reservoir , South North Water Transfer Project , Province City , Place Zhengzhou ,