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Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients


Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients
Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers. Now, researchers working in the U.S., Germany and China have shown how chemotherapy drugs called thiopurines can lead to mutations that set patients up for relapse. The work appears today in the journal
Nature Cancer.
The research provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy and are not always present at diagnosis.
The findings offer a paradigm shift in understanding how drug resistance develops. The results also suggest possible treatment strategies for ALL patients who relapse, including screening to identify those who should avoid additional thiopurine treatment. ....

Yao Chen , Chao Tang , Fan Yang , Li Xia , Bing Zhou , Benshang Li , Pandurang Kolekar , Huiying Sun , Hongzhuan Chen , Cornelia Eckert , Emily Henderson , Houshun Fang , Tianyi Wang , Jeffery Klco , Xiaotu Ma , Omkar Pathak , Jiaoyang Cai , Jinghui Zhang , Renate Kirschner Schwabe , Samuel Brady , Xiaomeng Li , Malwine Barz , Caiwen Duan , Shuhong Shen , Yu Liu , Shanghai Jiao Tong University School Of Medicine ,

International research team calls for 'glocal' approach to help mitigate flooding damage


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IMAGE: By coupling a large-scale hydrological model with a local-scale, high-resolution hydraulic model and urban flood model while integrating multiple sources of ground and satellite remote sensing data, a Glocal (global.
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Credit: Advances in Atmospheric Sciences
Large-scale global forecasting and on-the-ground observations need to meld into one system to better predict and prevent wide-spread flooding disasters, according to an international research team who published a short view in
A glocal global to local hydrometeorological solution for floods is considered to be critical for better preparedness, mitigation, and management of different types of significant precipitation-caused flooding, which happen extensively almost every year and in many countries, such as China, India and the United States, said paper author Huan Wu, professor and deputy director in the Guangdong Province Key Laboratory for Climate Change and ....

Yangtze River , China General , United States , City Of , United Kingdom , Syun Chen , Zhong Lu , Qiang Zhu , Chuan Wu , Zhijun Huang , Zhifang Wu , Weitian Chen , Xiaomeng Li , Hui Xu , Lorenzo Alfieri , Guangdong Meteorological Center , National Meteorological Center , Guangdong Province Key Laboratory For Climate , University Of Maryland , University Of Colorado Boulder , Advances In Atmospheric Sciences On Dec , Guangdong Climate Center , School Of Atmospheric Sciences , University Of Bristol , Research Foundation , Guangxi Climate Center ,