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Abstract
Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide. Despite its widespread use, MMT is associated with a variety of adverse neurodevelopmental outcomes in exposed offspring, particularly cognitive impairments. The neurobiological abnormalities underlying these cognitive impairments are, however, poorly understood. This is, in part, due to a lack of animal models that represents the standard of care that methadone is administered in the clinic, with inconsistencies in the timing, doses and durations of treatment. Here we describe the characterisation of a clinically relevant rat model of MMT in which the long-term behavioural and neurobiological effects of prenatal methadone exposure can be assessed in adolescent offspring. Female Sprague-Dawley rats were treated orally with an ascending methadone dosage schedule (5, 10, 15, 20, 25 and 30 mg/kg/day), self-administered in drinking water prior to conception, through
New Waynesboro treatment center helping people with opioid addiction
New Waynesboro treatment center helping people with opioid addiction By Tara Todd | March 4, 2021 at 7:49 PM EST - Updated March 5 at 2:48 PM
WAYNESBORO, Va. (WVIR) - Thereâs a new opioid treatment center in the Shenandoah Valley hoping to help people overcome their substance abuse disorder, and it just opened up this week.
The director says the phones are already ringing. After three solid years of hard work to get there, MARC (Mid-Atlantic Recovery Center) is now seeing patients.
âIf you canât function in your daily life without the drug then you are dependent,â MARC Director Natalie Broadnax said.