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Researchers identify an unexpected effect for already characterized active substances


Researchers identify an unexpected effect for already characterized active substances
Every innovative drug starts with the search for an active substance targeting key players in disease-related processes. However, there is no perfect drug that affects the one target in the body: no effect without side effects, as also described in most medicine information leaflets. A group of chemists and biologists led by Prof. Herbert Waldmann and Dr. Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund have now combined different strategies to find bioactive molecules and identified an unexpected effect for a group of already characterized active substances: they all modulate cholesterol metabolism, a home-made problem, as it seems. ....

Slava Ziegler , Tabea Schneidewind , Herbert Waldmann , Alexander Flemming , Emily Henderson , Max Planck Institute Of Molecular Physiology , Max Planck Institute , Molecular Physiology , Cell Painting Assay , ஹெர்பர்ட் வால்ட்மேன் , அலெக்சாண்டர் பிளெமிங் , எமிலி ஹென்டர்சன் , மூலக்கூறு உடலியல் ,

Eggs and embryos go through a more dynamic and complex journey than previously thought


Eggs and embryos go through a more dynamic and complex journey than previously thought
The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging.
Looking to shed new light on the dynamics of the eggs prior to fertilization and embryo transport preceding implantation, researchers at Baylor College of Medicine and Stevens Institute of Technology developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.
Published in the journal ....

Shang Wang , Emily Henderson , Baylor College Of Medicine , Stevens Institute Of Technology , Baylor College , Stevens Institute , Cell Reports , Irina Larina , Study Corresponding Author , Associate Professor , Molecular Physiology , Biomedical Engineering , ஷாங்க் வாங் , எமிலி ஹென்டர்சன் , பேலர் கல்லூரி ஆஃப் மருந்து , ஸ்டீவன்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , பேலர் கல்லூரி , ஸ்டீவன்ஸ் நிறுவனம் , செல் அறிக்கைகள் , இரினா லாரினா , இணை ப்ரொஃபெஸர் , மூலக்கூறு உடலியல் , உயிர் மருத்துவ பொறியியல் ,