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The Foundation for the NIH investigates metabolic disease links

The Foundation for the NIH, in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases, announced a new partnership to investigate links across serious common diseases. To better understand the molecular basis and discover disease targets and biomarkers, the Accelerating Medicines Partnership for Common Metabolic Diseases will focus on clarifying the links between ....

Mariac Freire , Eli Lilly , National Institute Of Diabetes , Medicines Partnership For Common Metabolic Diseases , Novo Nordisk , National Institute , Kidney Diseases , Accelerating Medicines Partnership , Common Metabolic Diseases , Medicines Partnership , எலி லில்லி , தேசிய நிறுவனம் ஆஃப் நீரிழிவு நோய் , தேசிய நிறுவனம் , கிட்நீ நோய்கள் , முடுக்கி மருந்துகள் கூட்டு , மருந்துகள் கூட்டு ,

Public vote for life-changing Aberdeen groups vying for share of £150,000

A public vote has opened to determine which Aberdeen groups, helping people with drugs and alcohol issues, could be awarded a share of £150,000. ....

Aberdeen City , United Kingdom , Simon Rayner , Chris Sumner , Aberdeen City Alcohol Drugs Partnership , Locality Improvement Fund Alcohol , Aberdeen City Council , Alcohol And Drugs Action , His Majesty , Aberdeen City Alcohol , Drugs Partnership , Locality Improvement Fund , Evening Express , குட்டைநாய் வகை நகரம் , ஒன்றுபட்டது கிஂக்டம் , சிமோன் ரேநர் , கிறிஸ் சம்னர் , குட்டைநாய் வகை நகரம் ஆல்கஹால் மருந்துகள் கூட்டு , குட்டைநாய் வகை நகரம் சபை , அவரது கம்பீரம் , குட்டைநாய் வகை நகரம் ஆல்கஹால் , மருந்துகள் கூட்டு , சாயங்காலம் எக்ஸ்பிரஸ் ,

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
Vijay R. Varma ,
Roles
Conceptualization,
Data curation,
Formal analysis,
Investigation,
Methodology,
Project administration,
Supervision,
Visualization,
Writing – original draft,
Writing – review & editing
¶‡ These authors share first authorship on this work.
Affiliation
Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America
¶‡ These authors share first authorship on this work.
Affiliation
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yang An, ....

United Kingdom , Lilliana Posey , Carol Brayne , National Cancer Institute , National Institute On , University Of Cambridge , Clinical Practice Research Datalink , Alzheimer Disease Metabolomics Consortium , Hepatocyte Nuclear Factor , Groupa Member , Laboratory Of Behavioral Neuroscience , Grouph Member , Alzheimer Disease Neuroimaging Initiative , Alzheimer Disease Neuroimaging Network , Groupi Member , Consortium Molecular Mechanisms Of The Vascular Etiology , Medicines Partnership , Groupc Member , Nuclear Receptor , Scientific Advisory Committee , National Institute On Aging , Baltimore Longitudinal Study , Disease Neuroimaging Initiative , Religious Orders Study , Aging Project , Creative Commons ,

Changes in how cholesterol breaks down in the body may accelerate progression of dementia

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IMAGE: Investigators with the National Institute on Aging, part of the National Institutes of Health, are searching for drug candidates that may correct the brain s metabolic abnormalities, such as cholesterol breakdown.
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Credit: Dr. Vijay R. Varma
The blood-brain barrier is impermeable to cholesterol, yet high blood cholesterol is associated with increased risk of Alzheimer s disease and vascular dementia. However, the underlying mechanisms mediating this relationship are poorly understood. A study published in the open-access journal
PLOS Medicine by Vijay Varma and colleagues at the National Institute on Aging, part of the National Institutes of Health, in Baltimore, Maryland, suggests that disturbances in the conversion of cholesterol to bile acids (called cholesterol catabolism) may play a role in the development of dementia. ....

National Institutes Of Health , United States , United Kingdom , Lilliana Posey , Madhav Thambisetty , Vijay Varma , National Cancer Institute , Alzheimer Disease Neuroimaging Initiative , Consortium Molecular Mechanisms Of The Vascular Etiology , National Institute On , Research Article , Medicines Partnership , Laboratory Of Behavioral Neuroscience , National Institute On Aging , National Institute , National Institutes , Baltimore Longitudinal Study , Disease Neuroimaging Initiative , Translational Neuroscience , Drug Repurposing , Effective Alzheimer , Accelerated Medicines Partnership , Target Discovery , Preclinical Validation Project , Molecular Mechanisms , Vascular Etiology ,

New drugs and alcohol deputy chairman first with 'lived experience'

20/05/2021, 11:45 am
Scotland’s first alcohol and drugs boss with “lived experience” of addiction says the entire approach to substance misuse must change to halt the rise in deaths.
Dermot Craig has been named the new deputy chairman of Aberdeen City Alcohol & Drugs Partnership (ADP) – with his appointment thought to be the first of its kind in Scotland.
But he says too much focus has been placed on the “tip of the iceberg” and is calling for more attention to be given to the many underlying issues at hand.
Earlier this year health chiefs issued an urgent warning when “upwards of 10 suspected deaths” from drugs took place in Aberdeen in the space of just a few weeks. ....

United Kingdom , Aberdeen City , Simon Rayner , Dermot Craig , Angela Constance , Nicola Sturgeon , Joe Fitzpatrick , National Records Of Scotland , Aberdeen City Alcohol Drugs Partnership , Aberdeen City Alcohol , Drugs Partnership , Aberdeen In Recovery , National Records , First Minister Nicola , ஒன்றுபட்டது கிஂக்டம் , குட்டைநாய் வகை நகரம் , சிமோன் ரேநர் , டெர்மோட் கிரேக் , ஏஞ்சலா நிலைத்தன்மை , நிகோலா ஸ்டர்ஜன் , ஓஹோ ஃபிட்ஸ்‌ப்யாட்ரிக் , தேசிய பதிவுகள் ஆஃப் ஸ்காட்லாந்து , குட்டைநாய் வகை நகரம் ஆல்கஹால் மருந்துகள் கூட்டு , குட்டைநாய் வகை நகரம் ஆல்கஹால் , மருந்துகள் கூட்டு , குட்டைநாய் வகை இல் மீட்பு ,