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SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

Science for just $15 USD.
Short circuiting solid tumors
Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape due to antigen loss. To address these challenges, Hyrenius-Wittsten
et al. and Choe
et al. developed synthetic Notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma. In both studies, the authors demonstrated that synNotch-CAR T cells were better at controlling tumors than traditional CAR T cells and did not result in toxicity or damage to healthy tissue. These results suggest that synNotch-CAR T cells may be an effective treatment strategy for solid tumors. ....

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How to Boost Genome Editing/Genome Engineering Market Forecast Covering Growth Inclinations & Development Strategies until 2025 – KSU

How to Boost Genome Editing/Genome Engineering Market Forecast Covering Growth Inclinations & Development Strategies until 2025 – KSU
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Koronavirus mutasiyaları: Hansı daha təhlükəlidir?

Koronavirus mutasiyaları: Hansı daha təhlükəlidir?
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CRISPR and CAS Gene Market to Score Past US$ 7,603.8 Million Valuation by 2027: CMI – KSU

CRISPR and CAS Gene Market to Score Past US$ 7,603.8 Million Valuation by 2027: CMI – KSU
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Nanotechnology for Plant Genetic Engineering

Nanotechnology for Plant Genetic Engineering
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