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Do Gene Expression Signatures of Aging Signal AD? alzforum.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from alzforum.org Daily Mail and Mail on Sunday newspapers.
Alzheimer's fight the reason for Mayo Clinic's $33 million grant jacksonville.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from jacksonville.com Daily Mail and Mail on Sunday newspapers.
25 Apr 2021 In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant transcripts, stathmin-2, has been tied to disease pathology. Now, two preprints uploaded to bioRXiv on April 4 detail another UNC13A. Variants in this gene increase risk for ALS/FTD. Neurons lacking nuclear TDP-43 mis-splice UNC13A, make less of the protein. UNC13A risk variants incorporate cryptic exons. This only occurs in brain and spinal cord tissue harboring TDP-43 deposits. One paper was penned by researchers led by Pietro Fratta, University College London, and Michael Ward, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. The second is from the labs of Aaron Gitler, Stanford University, California, and Leonard Petrucelli, Mayo Clinic, Jacksonville, Florida. Both papers report that if TDP-43 binding to UNC13A falters, t ....
Date Time Mayo researchers, collaborators identify ‘instigator’ gene associated with Alzheimer’s disease JACKSONVILLE, Fla. – In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of the gene to Alzheimer’s disease. The researchers used tissue samples from 385 brains donated to the Mayo Clinic Brain Bank, which houses more than 9,000 brain tissue specimens for the study of neurodegenerative disorders. The samples were from people who were diagnosed with Alzheimer’s disease and lacked co-existing diseases found in the brain. This ensured a spotlight on Alzheimer’s disease, which enabled the team to focus on targets relevant to t ....
In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of the gene to Alzheimer’s disease. The researchers used tissue samples from 385 brains donated to the Mayo Clinic Brain Bank, which houses more than 9,000 brain tissue specimens for the study of neurodegenerative disorders. The samples were from people who were diagnosed with Alzheimer’s disease and lacked co-existing diseases found in the brain. This ensured a spotlight on Alzheimer’s disease, which enabled the team to focus on targets relevant to the disease. ....