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Credit: Garvan Institute of Medical Research Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....
Researchers find new map revealing genes that control skeleton ANI | Updated: May 05, 2021 16:10 IST Sydney [Australia], May 5 (ANI): Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapi ....
Image for representational purpose only |Pic: Pixabay Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....
Researchers have mapped the gene activity of osteocytes to improve their understanding of skeletal disease. Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton’s ‘master regulator’ cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. “This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component,” says the study’s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. “Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton.” ....
E-Mail Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The new cells, which the researchers term osteomorphs , are found in the blood and bone marrow, and fuse together to form osteoclasts, specialised cells that break down bone tissue. They have a unique genomic profile that reveals promising and as yet unexplored targets for therapy. This discovery is a game-changer, which not only helps us understand bone biology but presents significant new in-roads for osteoporosis therapy, says co-senior author Professor Tri Phan, who heads the Intravital Microscopy and Gene Expression Lab at the Garvan Institute. Osteomorphs express several genes that seem to be linked to bone disease, which could lead scientists to entirely new ways to target osteoporosis. ....