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New Genetic Map Expands Understanding of Skeletal Disease X ray of knees. [Garvan Institute of Medical Research] May 7, 2021 Share Bone mainly contains three types of cells: osteocytes, osteoblasts, and osteoclasts. The osteocytes are the most abundant cells comprising 95% of the total cell population in bone with an average half-life of 25 years. Osteocytes can also be responsible for not only bone diseases and disorders, but also those of the kidney, heart, and potentially muscle. Now researchers at the Garvan Institute of Medical Research have for the first time mapped the unique genetic profile of osteocytes. This new genetic map can help lead to new therapeutics and a better understanding of bone diseases and the impacts of current skeletal therapies. ....
Credit: Garvan Institute of Medical Research Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....
Researchers find new map revealing genes that control skeleton ANI | Updated: May 05, 2021 16:10 IST Sydney [Australia], May 5 (ANI): Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapi ....
Image for representational purpose only |Pic: Pixabay Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....
Researchers have mapped the gene activity of osteocytes to improve their understanding of skeletal disease. Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton’s ‘master regulator’ cells, known as osteocytes. The study published today in Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones. “This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component,” says the study’s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. “Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton.” ....