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Research uncovers an unexpected role for immune T cells in protection against malaria

Research uncovers an unexpected role for immune T cells in protection against malaria
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
An international team used mass cytometry - an in-depth way of characterizing individual cells - and machine learning to discover immune signatures associated with symptomatic or asymptomatic infections in people infected with the Plasmodium vivax parasite. This uncovered an unexpected role for immune T cells in protection against malaria, a finding that could help to improve the development of much-needed malaria vaccines. ....

United States , Lisa Ioannidis , Diana Hansen , Gordon Smyth , Rintis Noviyanti , Emily Henderson , Eijkman Institute For Molecular Biology , University Of Melbourne , Menzies School Of Health Research , Associate Professor Diana Hansen , Professor Ric Price , Menzies School , Health Research , Eijkman Institute , Molecular Biology , Associate Professor Hansen , Professor Gordon Smyth , Professor Hansen , ஒன்றுபட்டது மாநிலங்களில் , டயானா ஹேன்சன் , கோர்டந் ஸ்மித் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் , மென்ஸீஸ் பள்ளி ஆஃப் ஆரோக்கியம் ஆராய்ச்சி , மென்ஸீஸ் பள்ளி , ஆரோக்கியம் ஆராய்ச்சி ,

New insights into immune responses to malaria

Date Time
New insights into immune responses to malaria
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
Dr Lisa Ioannidis (left) and Associate Professor Diana
Hansen (right) have led a study into why some people
develop serious illness as a result of malaria infections.
An international team used mass cytometry – an in-depth way of characterising individual cells – and machine learning to discover ‘immune signatures’ associated with symptomatic or asymptomatic infections in people infected with the Plasmodium vivax parasite. This uncovered an unexpected role for immune T cells in protection against malaria, a finding that could help to improve the development of much-needed malaria vaccines. ....

United States , Dylan Sheerin , Stephanie Studniberg , Gordon Smyth , Connie Li , Lisa Ioannidis , Emily Eriksson , Halina Pietrzak , Diana Hansen , Alan Cowman , Waruni Abeysekera , Rintis Noviyanti , Eijkman Institute For Molecular Biology , Australian National Health , Menzies School Of Health Research , Indonesian Ministry Of Research , University Of Melbourne , Australian Academy Of Science , Research Council , Associate Professor , Associate Professor Diana Hansen , Professor Ric Price , Menzies School , Health Research , Eijkman Institute , Molecular Biology ,

New cellular atlas maps out healthy and cancerous breast tissue

Date Time
New cellular atlas maps out healthy and cancerous breast tissue
WEHI researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.
The diversity of cells in the human breast has been
documented in a new ‘RNA atlas’.
The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an ‘RNA atlas’ that details the different cells found in these tissues. ....

Tony Papenfuss , Jane Visvader , Geoff Lindeman , Gordon Smyth , Yunshun Chen , Rachel Joyce , Bhupinder Pal , Stephen Wilcox , Jocelyn Penington , Vanessa Bryant , Nina Tubau Ribera , Bianca Capaldo , National Health , Qualtrough Cancer Research Fund , Michael Heine Family Foundation , Ian Potter Foundation , Australian Cancer Research Foundation , National Breast Cancer Foundation , Research Council , Olivia Newton John Cancer Research Institute , Professor Jane Visvader , Professor Gordon Smyth , Professor Geoff , Professor Visvader , Professor Smyth , Victorian Cancer Biobank ,

MP for Vale of Clwyd questions medical experts on scan at 36 weeks to help detect breech pregnancies

Dr James Davies, MP for Vale of Clwyd, questioned medical experts on the matter in parliament.
At last week’s health and social care select committee, Professor Gordon Smith, head of department of Obstetrics and Gynaecology, University of Cambridge, told members that they are thinking about a scan at 36 weeks to try to stratify women for risk as they are making plans around location and type of birth.
He said a third scan at 36 weeks would be particularly helpful in detecting breech pregnancies.
He added: “One open goal at the moment is the presentation of the baby. Midwives routinely perform palpation to determine whether the baby is head first or otherwise, but we know from research that anybody doing palpation detects about 50 per cent to 70 per cent of non-cephalic presentation and misses the remainder. In cases where the diagnosis is not made, the woman loses the opportunity to have interventions. ....

United Kingdom General , United Kingdom , James Davies , Gordon Smith , University Of Cambridge , Professor Gordon Smith , Professor Smith , ஒன்றுபட்டது கிஂக்டம் ஜநரல் , ஒன்றுபட்டது கிஂக்டம் , ஜேம்ஸ் டேவிஸ் , கோர்டந் ஸ்மித் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , ப்ரொஃபெஸர் கோர்டந் ஸ்மித் , ப்ரொஃபெஸர் ஸ்மித் ,

Surviving birth

Surviving birth
Valente Inziku, whose wife Jennifer died in childbirth in Arua, Uganda (photography: Tadej Znidarcic)
Researchers at one of the busiest maternity hospitals in the world aim to help more women survive complications giving birth.
Obstetrician Dr Annettee Nakimuli and colleagues look after up to 28,000 births a year at Mulago Hospital in Kampala, Uganda.
Every day, 300 pregnant women visit the hospital antenatal clinic. Around 100 women are on the labour ward, and 40 of these will have complications – obstructed labour, haemorrhage, sepsis or pre-eclampsia – requiring up to 25 emergency caesarean sections to be carried out.
“When women come to the labour ward they hope to come out with the best of it – they hope to come out with a live baby, and come out alive themselves. But women go to hospital with mixed feelings – they’ve seen others die before them, so there’s a tendency to think of maternal death as something inevitable rather ....

United Kingdom , Lloyd Mann , Gordon Smith , Catherine Aiken , Annettee Nakimuli , Graham Burton , Ashley Moffett , Margherita Turco , Imelda Namagembe , Cambridge University , Royal Society , Department Of Obstetrics , Makerere University , World Health Organization , Africa Programme , Cambridge University Press , Cambridge Department Of Obstetrics , Department Of Pathology , Cambridge Global Health Partnerships , Cambridge University Hospitals , Cambridge Department Of Pathology , African Academy Of Sciences , Obstetrician Dr Annettee Nakimuli , Mulago Hospital , Saharan Africa , World Health ,