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Research uncovers an unexpected role for immune T cells in protection against malaria


Research uncovers an unexpected role for immune T cells in protection against malaria
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
An international team used mass cytometry - an in-depth way of characterizing individual cells - and machine learning to discover immune signatures associated with symptomatic or asymptomatic infections in people infected with the Plasmodium vivax parasite. This uncovered an unexpected role for immune T cells in protection against malaria, a finding that could help to improve the development of much-needed malaria vaccines. ....

United States , Lisa Ioannidis , Diana Hansen , Gordon Smyth , Rintis Noviyanti , Emily Henderson , Eijkman Institute For Molecular Biology , University Of Melbourne , Menzies School Of Health Research , Associate Professor Diana Hansen , Professor Ric Price , Menzies School , Health Research , Eijkman Institute , Molecular Biology , Associate Professor Hansen , Professor Gordon Smyth , Professor Hansen , ஒன்றுபட்டது மாநிலங்களில் , டயானா ஹேன்சன் , கோர்டந் ஸ்மித் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் , மென்ஸீஸ் பள்ளி ஆஃப் ஆரோக்கியம் ஆராய்ச்சி , மென்ஸீஸ் பள்ளி , ஆரோக்கியம் ஆராய்ச்சி ,

New insights into immune responses to malaria


Date Time
New insights into immune responses to malaria
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
Dr Lisa Ioannidis (left) and Associate Professor Diana
Hansen (right) have led a study into why some people
develop serious illness as a result of malaria infections.
An international team used mass cytometry – an in-depth way of characterising individual cells – and machine learning to discover ‘immune signatures’ associated with symptomatic or asymptomatic infections in people infected with the Plasmodium vivax parasite. This uncovered an unexpected role for immune T cells in protection against malaria, a finding that could help to improve the development of much-needed malaria vaccines. ....

United States , Dylan Sheerin , Stephanie Studniberg , Gordon Smyth , Connie Li , Lisa Ioannidis , Emily Eriksson , Halina Pietrzak , Diana Hansen , Alan Cowman , Waruni Abeysekera , Rintis Noviyanti , Eijkman Institute For Molecular Biology , Australian National Health , Menzies School Of Health Research , Indonesian Ministry Of Research , University Of Melbourne , Australian Academy Of Science , Research Council , Associate Professor , Associate Professor Diana Hansen , Professor Ric Price , Menzies School , Health Research , Eijkman Institute , Molecular Biology ,