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Credit: Courtesy of Van Andel Institute GRAND RAPIDS, Mich. (Feb. 9, 2021) Scientists have devised a new approach for detecting and potentially heading off the effects of two rare pediatric diseases before birth. The study, performed in mouse models of the diseases and published today in Cell Reports, represents an important step toward much-needed early interventions for Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Both diseases result in growth-related symptoms in children and often lead to additional problems later in life, such as increased cancer risk from Beckwith-Wiedemann syndrome and increased metabolic disease risk from Silver-Russell syndrome. Both of these diseases have lifelong consequences, said Piroska Szabó, Ph.D., an associate professor at Van Andel Institute and the study s corresponding author. Our findings provide a critical foundation for additional studies that we hope will translate into new, life-changing prenatal de ....