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ACTION: Full-Dose Rivaroxaban Doesn't Help in Hospitalized COVID-19


May 17, 2021
Therapeutic-dose anticoagulation primarily consisting of rivaroxaban (Xarelto; Bayer/Janssen), compared with standard thromboprophylaxis, does not improve outcomes in patients hospitalized with COVID-19 who have elevated D-dimer levels, according to results from the randomized ACTION trial.
A “win ratio” analysis indicated that full-dose anticoagulation was no better, and potentially worse, than usual care in terms of a hierarchical composite endpoint of mortality, duration of hospitalization, and duration of oxygen use through 30 days, Renato Lopes, MD, PhD (Duke Clinical Research Institute, Durham, NC), reported over the weekend during the virtual American College of Cardiology 2021 Scientific Session.
A composite of thromboembolic events occurred at a numerically but nonsignificantly lower rate in the therapeutic-dose group (7.4% vs 9.9%), although that was offset by a nonsignificant increase in all-cause mortality (11.3% vs 7.6%) and a substantial ....

Edward Fry , Renato Lopes , Bayer Janssen , Md Ascension Medical Group , Phd Duke Clinical Research Institute , American College Of Cardiology , Duke Clinical Research Institute , American College , President Edward Fry , Ascension Medical Group , எட்வர்ட் வறுக்கவும் , ரெனாடோ லோப்ஸ் , பேயர் ஜான்சன் , ம்ட் ஏற்றம் மருத்துவ குழு , ஃப்ட் டியூக் மருத்துவ ஆராய்ச்சி நிறுவனம் , அமெரிக்கன் கல்லூரி ஆஃப் இருதயவியல் , டியூக் மருத்துவ ஆராய்ச்சி நிறுவனம் , அமெரிக்கன் கல்லூரி , ஏற்றம் மருத்துவ குழு ,