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New Method Holds Potential to Fight Botulinum Toxin

New Method Holds Potential to Fight Botulinum Toxin
by Angela Mohan on
January 7, 2021 at 3:23 PM
Science Translational Medicine by Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine.
Furthermore, in a companion article, an independent team demonstrated that a related drug has robust efficacy in mice.
This is one of those serendipitous moments in science where two groups, working independently, demonstrate similar results for a long-standing problem, McNutt said.
We are currently modifying this drug to enhance its therapeutic properties against botulism and exploring whether the same approach can be repurposed to treat other neuronal diseases.
In 2010, Konstantin Ichtchenko (New York University School of Medicine) conceived of a novel trojan horse strategy to treat botulism. This strategy is based on using a non-toxic form of BoNT to deliver therapeutic antibodies to paralyzed neurons, blocking wild-t ....

Patrick Mcnutt , Wake Forest Institute For Regenerative Medicine , Science Translational Medicine , Wake Forest Institute , Botulinum Toxin , Guinea Pigs , Rhesus Macaque Monkeys , Therapeutic Effect , பேட்ரிக் ம்க்ணுத்த் , எழுந்திரு காடு நிறுவனம் க்கு மீளுருவாக்கம் மருந்து , அறிவியல் மொழிபெயர்ப்பு மருந்து , எழுந்திரு காடு நிறுவனம் , கினியா பன்றிகள் , சிகிச்சை விளைவு ,

Non-toxic versions of botulism toxins can deliver therapeutic antibodies to treat botulism

Non-toxic versions of botulism toxins can deliver therapeutic antibodies to treat botulism
Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments.
The research, which was conducted in mice, guinea pigs, and nonhuman primates, suggests that the toxin derivatives could one day offer a platform to quickly treat established cases of botulism and target hard-to-reach molecules within neurons. Botulism manifests due to bacterial toxins called botulinum neurotoxins (BoNTs), which are the most potent toxins known to humans. ....

Shin Ichiro Miyashita , Patrick Mcnutt , Emily Henderson , பேட்ரிக் ம்க்ணுத்த் , எமிலி ஹென்டர்சன் ,

Toxin chimeras slip therapeutics into neurons to treat botulism in animals

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IMAGE: Schematic showing how the chimera molecule (BoNT/XA) delivers nanobodies to neurons to neutralize botulism neurotoxins. This material relates to a paper that appeared in the Jan. 6, 2021, issue of.
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Credit: [Credit: S.-I. Miyashita
et al., Science Translational Medicine (2021)]
Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. The research, which was conducted in mice, guinea pigs, and nonhuman primates, suggests that the toxin derivatives could one day offer a platform to quickly treat established cases of botulism and target hard-to-reach molecules within neurons. Botulism manifests due to bacterial toxins called botulinum neurotoxins (BoNTs), which are the most potent toxins known to humans. BoNTs work by entering and ....

Shin Ichiro Miyashita , Patrick Mcnutt , பேட்ரிக் ம்க்ணுத்த் ,

New strategy to fight botulinum toxin - expert available

Related to new research published in the January issue of
Science Translational Medicine, Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine, was part of the research team that demonstrated a new Trojan horse approach that produces strong antidotal efficacy in treating lethal botulism in mice, guinea pigs and rhesus macaque monkeys.
Furthermore, in a companion article, an independent team demonstrated that a related drug has robust efficacy in mice.
This is one of those serendipitous moments in science where two groups, working independently, demonstrate similar results for a long-standing problem, McNutt said. We are currently modifying this drug to enhance its therapeutic properties against botulism and exploring whether the same approach can be repurposed to treat other neuronal diseases. ....

Patrick Mcnutt , Chuck Shoemaker Tufts University , Phil Band Cytodel Inc , Wake Forest Institute For Regenerative Medicine , Science Translational Medicine , Wake Forest Institute , Regenerative Medicine , Konstantin Ichtchenko , New York University School , Phil Band , Chuck Shoemaker , Tufts University , பேட்ரிக் ம்க்ணுத்த் , சக் ஷூ தயாரிப்பாளர் டஃப்ட்ஸ் பல்கலைக்கழகம் , எழுந்திரு காடு நிறுவனம் க்கு மீளுருவாக்கம் மருந்து , அறிவியல் மொழிபெயர்ப்பு மருந்து , எழுந்திரு காடு நிறுவனம் , மீளுருவாக்கம் மருந்து , புதியது யார்க் பல்கலைக்கழகம் பள்ளி , பில் இசைக்குழு , சக் ஷூ தயாரிப்பாளர் , டஃப்ட்ஸ் பல்கலைக்கழகம் ,