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Researchers are enrolling healthy volunteers for an outpatient research study to learn more about how the brain works. Research participation may include cognitive tasks, personality tests, brain imaging and/or magnetoencephalography (MEG). Participants may choose which research tasks they would like to participate in, which determines the number of visits (1-12) to the NIH Clinical Center in Bethesda, MD. The study is enrolling eligible participants, between the ages of 18 and 65, who are in good physical health, and at least a high school education. There is no cost to participate and compensation is provided. To find out if you qualify, The purpose of this research study is to better understand how the brain and body work when healthy volunteers feel anxious. ....
The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeated doses of ketamine in the brain. We want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. Also, we want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression. We are enrolling eligible adults, ages 18 to 65 with major depressive disorder. This inpatient study lasts 14-20 weeks and procedures include a medication taper and drug-free period, taking repeated doses of the research drug, two infusions of placebo, multiple brain imaging scans, transcranial magnetic stimulation, and psychological testing. After completing the study, participants can receive short-term care at the NIH while transitioning back to a provider. ....
Torrisi, S, Gorka, AX, Gonzalez-Castillo, J, Balderston, NL, Grillon, C, & Ernst, M (2018). Extended amygdala connectivity changes during sustained shock anticipation. Translational Psychiatry. 8(33) 2017 Balderston, NL, Liu, J, Roberson-Nay, R, Ernst, M, & Grillon, C (2017). The relationship between dlPFC activity during unpredictable threat and CO2-induced panic symptoms. Translational Psychiatry, 7(12), 1266. Balderston NL, Hsiung A, Ernst M, Grillon C (2017) The effect of threat on right dlPFC activity during behavioral pattern separation. J Neurosci 37:0717–17. Balderston NL, Hsiung A, Liu J, Ernst M, Grillon C (2017) Reducing State Anxiety Using Working Memory Maintenance. J Vis Exp:1–11. Balderston NL, Hale E, Hsiung A, Torrisi S, Holroyd T, Carver FW, Coppola R, Ernst M, Grillon C (2017) Threat of shock increases excitability and connectivity of the intraparietal sulcus. Elife 6:1–27. ....