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Metagenomic Analyses Used to Identify Changes in Gut Microbiome After Spinal Cord Injury

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Metagenomic Analyses Used to Identify Changes in Gut Microbiome After Spinal Cord Injury
Using metagenomic sequencing, researchers have identified changes in populations of bacteria and viruses that occur after spinal cord injuries in mice. The novel metagenomic data sets, presented in
mSystems, an open-access journal of the American Society for Microbiology, provide new information on the taxonomy and function of diverse microbes, including viruses. This information may help to better predict how spinal cord injury-induced changes in the microbiome influence systemic and neurological outcomes after traumatic spinal cord injury.
“This is the first study that has applied metagenomics to characterize gut dysbiosis after spinal cord injury,” said principal study investigator Phillip Popovich, PhD, Professor and Chair of the Department of Neuroscience and Executive Director of the Belford Center for Spinal Cord Injury at the Ohio State University (OSU). ....

United States , Matthew Sullivan , Phillip Popovich , American Society For Microbiology , Belford Center , Department Of Microbiology , Ohio State University , Department Of Neuroscience , American Society , Executive Director , Spinal Cord Injury , Founding Director , Microbiome Science , ஒன்றுபட்டது மாநிலங்களில் , மேத்யூ சல்லிவன் , பிலிப் பொப்பொவிச் , அமெரிக்கன் சமூகம் க்கு நுண்ணுயிரியல் , பெல்ஃபோர்ட் மையம் , துறை ஆஃப் நுண்ணுயிரியல் , ஓஹியோ நிலை பல்கலைக்கழகம் , துறை ஆஃப் நரம்பியல் , அமெரிக்கன் சமூகம் , நிர்வாகி இயக்குனர் , முதுகெலும்பு தண்டு காயம் , ஸ்தாபகம் இயக்குனர் ,

UMass Memorial forced to pause new vaccine appointments for 2-3 weeks

UMass Memorial Health Care is temporarily stopping new appointments for COVID-19 vaccines for patients because of a dose shortage, with the announcement to staff on Friday coming less than a week after the Worcester hospital system opened a patient vaccine center at the Mercantile Center.
Dr. Eric Dickson, UMass Memorial s president and CEO, said in a staff advisory it won t be booking any new appointments at any patient vaccine clinics for two to three weeks. The decision came after talks with state officials and leaders of other health care systems in Massachusetts, he said, with Gov. Charlie Baker giving priority to patients who have already booked appointments. ....

United States , Natick Mall , Eric Dickson , Charlie Baker , Worcester State University , Belford Center , International Affairs On , Mercantile Center , Massachusetts Department Of Public Health , Umass Memorial Health Care , Memorial Health Care , Massachusetts Department , International Affairs , ஒன்றுபட்டது மாநிலங்களில் , நாட்டிக் மால் , எரிக் டிக்சன் , சார்லி ரொட்டி சுடுபவர் , வர்ஸெஸ்டர் நிலை பல்கலைக்கழகம் , பெல்ஃபோர்ட் மையம் , சர்வதேச வாழ்க்கைத்தொழில்கள் ஆன் , வணிக மையம் , மாசசூசெட்ஸ் துறை ஆஃப் பொது ஆரோக்கியம் , உமஸ்ஸ் நினைவகம் ஆரோக்கியம் பராமரிப்பு , நினைவகம் ஆரோக்கியம் பராமரிப்பு , மாசசூசெட்ஸ் துறை , சர்வதேச வாழ்க்கைத்தொழில்கள் ,

Mouse study: gabapentin prevents harmful structural changes in spinal cord

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IMAGE: Phillip Popovich is a professor and chair of Ohio State s Department of Neuroscience and Executive Director of the Belford Center for Spinal Cord Injury at The Ohio State University College.
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Credit: The Ohio State University Wexner Medical Center
COLUMBUS, Ohio - Research led by The Ohio State University Wexner Medical Center and College of Medicine found that the widely prescribed pain-relief drug gabapentin can prevent harmful structural changes in the injured spinal cords of mice, and also block cardiovascular changes and immune suppression caused by spinal cord injury.
Gabapentin is often prescribed as a treatment for pain, but if it is given early after injury - before symptoms develop - it can also limit structural changes in nerve cells. We show that these benefits remain even one month after stopping gabapentin treatment in spinal injured mice. We believe that gabapentin could be repurposed as a prophylactic therap ....

United States , Rayw Poppleton , Phillip Popovich , Us Department Of Defense , Belford Center , National Institutes Of Health , Ohio State Department , Ohio State Department Of Neuroscience , Ohio State University Wexner Medical Center , Ohio State Neurological Institute , Craigh Neilsen Foundation , College Of Medicine , University Of California San Francisco , Ohio Department Of Higher Education , Duke University , Ohio State , Faith Brennan , Neurological Institute , Spinal Cord , California San Francisco , National Institutes , Ohio Department , ஒன்றுபட்டது மாநிலங்களில் , பிலிப் பொப்பொவிச் , எங்களுக்கு துறை ஆஃப் பாதுகாப்பு , பெல்ஃபோர்ட் மையம் ,