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COVID-19 is more difficult to diagnose in children and adolescents, finds study

COVID-19 is more difficult to diagnose in children and adolescents, finds study
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread to over 192 countries and territories, causing an enormous loss of lives and economic devastation.
The clinical presentation of this disease varies hugely between individuals, causing asymptomatic or mild infection in most cases but leading to life-threatening disease in about 15% of infections. Only about 0.4% of cases have been diagnosed in children below 10 years of age.
medRxiv preprint server, deals with the clinical presentation, tests and complications in children and adolescents with COVID-19. ....

Liji Thomas , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , D Dimer , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , படம் கடன் , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Quantum dot-based affinity biosensors in microfluidic systems offer an alternative SARS-CoV-2 diagnostics platform

Quantum dot-based affinity biosensors in microfluidic systems offer an alternative SARS-CoV-2 diagnostics platform
In a new study published in
Emergent Materials, researchers show how microfluidic systems integrated with quantum dot-based affinity biosensors can serve as a valuable platform to rapidly and accurately diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
What are quantum dots?
Quantum dots (QD) are nanoscale semiconductor crystals (size: 2-10 nm) with unique optical and electronic characteristics. Such nanomaterials are widely used in biosensing applications for biomedical and bioanalytical purposes. Unlike organic dyes and protein-based fluorophores, QDs have a wide absorption spectrum and narrow emission bands, which make them very suitable for cell imaging and biosensor applications. Specifically, QDs can be used to trace multiple biological targets simultaneously with simple instrumentations. Other properties of QDs th ....

Sanchari Sinha Dutta , Emergent Materials , Coronavirus Disease Covid 19 , Sars Cov 2 , Cell Imaging , Corona Virus , Quantum Dots , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சஞ்சரி சீன்ஹா தத்தா , வெளிப்படுகிறது பொருட்கள் , செல் இமேஜிங் , கொரோனா வைரஸ் , குவாண்டம் புள்ளிகள் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

AI method can detect precursors to cervical cancer

Credit: Ulf Sirborn
Using artificial intelligence and mobile digital microscopy, researchers hope to create screening tools that can detect precursors to cervical cancer in women in resource-limited settings. A study led by researchers at Karolinska Institutet in Sweden now shows that AI screenings of pap smears carried out with portable scanners were comparable to analyses done by pathologists. The results are published in the journal
JAMA Network Open.
Our method enables us to more effectively discover and treat precursors to cervical cancer, especially in low-income countries, where there is a serious lack of skilled pathologists and advanced laboratory equipment, says corresponding author Johan Lundin, professor at the Department of Global Public Health, Karolinska Institutet. ....

Eteläuomen Läi , Uppsala Lan , Karolinska Institutet , Mikael Lundin , Felix Kinyua , Oscar Holmstr , Leena Krogerus , Ngali Mbuuko , Jumaa Mbete , Martin Muinde , Vinod Diwan , Nina Linder , Johan Lundin , Harrison Kaingu , Uppsala University , Erling Persson Family Foundation , University Of Helsinki , Elsa Stockmann Foundation , K Albin Johansson Foundation , Institute For Molecular Medicine Finland , Swedish Research Council , Finnish Society Of Medicine , Biomedicum Foundation , Department Of Global Public Health , Kinondo Kwetu Health Services Clinic , Global Public Health ,

A deep dive into cells' RNA reality

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IMAGE: The researchers compared the BOLORAMIS method with single-molecule FISH (smFISH) analysis, a common standard for RNA localization studies, by tracing the location of a long non-coding RNA molecule known as.
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Credit: Wyss Institute at Harvard University
(BOSTON) ¬ Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell. Many RNA molecules convey gene information from the cell s nucleus to the protein-synthesizing machinery distributed throughout the cytoplasm (messenger RNAs or mRNAs), others are components of that machinery itself, while still different ones regulate genes and their expression, or have functions that remain to be discovered. Importantly, many diseases including cancer and neurological diseases have sign ....

Boston University , United States , University Of Massachusetts Medical School , Massachusetts Institute Of Technology , Dana Farber Cancer Institute , Tufts University , Spaulding Rehabilitation Hospital , Bruce Yankner , Daniel Goodwin , Jenny Tam , Kunal Jindal , Valerie Willocq , Eswar Iyer , Songlei Liu , Je Hyuk Lee , Anubhav Sinha , Thomas Ferrante , Conor Camplisson , Donald Ingber , Benjamin Boettner , Katharina Meyer , Sukanya Punthambaker , Lauren Mifflin , Richie Kohman , Anne Cheng , Edward Boyden ,

Study finds significant variation in biomarker test utilization and treatment for non–small-cell lung cancer

Study finds significant variation in biomarker test utilization and treatment for non–small-cell lung cancer
Biomarker testing surveys specific disease-associated molecules to predict treatment response and disease progression; however its use has complicated the diagnosis of non-small-cell lung cancer (NSCLC). In a new study in
The
Journal of Molecular Diagnosis, published by Elsevier, investigators provide for the first time a complete overview of biomarker testing, spanning multiple treatment lines, in a single cohort of patients.
Using exploratory data analysis and process-mining techniques in a real-world setting, investigators identified significant variation in test utilization and treatment. They also found that while whole-genome sequencing, in which a patient s unique DNA is mapped at once, may not be a cost saving alternative to biomarker testing, as some have suggested, it may have other benefits for patients, such as decreasing the time between test ....

Maarten Ijzerman , Emily Henderson , University Of Twente , Services Research , Health Technology , University Of Melbourne Centre For Cancer Research , Techmed Center , Molecular Diagnosis , Professor Maarten , Melbourne Centre , Cancer Research , First Author , Phd Candidate , Lung Cancer , Molecular Diagnostics , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் இருபது , சேவைகள் ஆராய்ச்சி , ஆரோக்கியம் தொழில்நுட்பம் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் மையம் க்கு புற்றுநோய் ஆராய்ச்சி , தொழில்நுட்பம் மையம் , மூலக்கூறு நோயறிதல் , ப்ரொஃபெஸர் மார்டன் , மெல்போர்ன் மையம் , புற்றுநோய் ஆராய்ச்சி , முதல் நூலாசிரியர் ,