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Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema


Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema
Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells-the cells that line the walls of blood vessels in the lung-can reverse the symptoms of emphysema. The study, which will be published July 21 in the
Journal of Experimental Medicine (
JEM), may lead to new treatments for chronic obstructive pulmonary disease (COPD), an inflammatory lung disease associated with smoking that is thought to be the third leading cause of death worldwide.
Emphysema is one of the characteristic features of COPD in which the tiny air sacs, or alveoli, within the lungs are gradually destroyed, leading to breathing difficulties and, eventually, respiratory failure. The loss of alveoli is accompanied by a remodeling of the lung s blood vessels that could indicate changes in the endothelial cells that form the blood vesse ....

New York , United States , Shu Hisata , Arthurb Belfer , Emily Henderson , Weill Cornell , Shahin Rafii , Augustine Mk Choi , Angiocrine Bioscience , Alexandra Racanelli , Ansary Stem Cell Institute , Division Of Regenerative Medicine , Jichi Medical University , Weill Cornell Medicine , Experimental Medicine , Suzanne Weiss Dean , Co Senior Author , Regenerative Medicine , Genetic Medicine , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , வெயில் கார்னெல் , ஆகஸ்டின் ம்ஸீ சோய் , பதில் தண்டு செல் நிறுவனம் , பிரிவு ஆஃப் மீளுருவாக்கம் மருந்து ,

Study identifies major flaws in iBMEC-based models of the blood-brain barrier


Study identifies major flaws in iBMEC-based models of the blood-brain barrier
A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.
The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the blood-brain barrier.
Many brain diseases, including brain cancers as well as degenerative and genetic disorders, could be much more treatable if researchers could get drugs across this barrier. For that and other reasons, iBMEC-based models of the barrier have been embraced as an important standard tool in brain research. ....

Tyler Lu , Ronaldo Perelman , David Redmond , Emily Henderson , Columbia University Irving Medical Center , Claudia Cohen Center , Research Specialist , Proceedings Of The National Academy Sciences , Ansary Stem Cell Institute , Memorial Sloan Kettering Cancer Center , Weill Cornell Medicine , Columbia University Irving Medical , Brain Microvascular Endothelial Cell , National Academy , Regenerative Medicine , Weill Cornell , Reproductive Medicine , Study First , Endothelial Cell , Gene Expression , Stem Cells , Transcription Factors , டைலர் லு , ரொனள்டோ பெரல்மேன் , டேவிட் ரெட்மண்ட் , எமிலி ஹென்டர்சன் ,