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University of Helsinki: Large genomic analysis highlights COVID-19 risk factors


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In March of 2020, thousands of scientists around the world united to answer a pressing and complex question: what genetic factors influence why some COVID-19 patients develop severe, life-threatening disease requiring hospitalization, while others escape with mild symptoms or none at all?
A comprehensive summary of their findings to date, published in Nature, reveals 13 loci, or locations in the human genome, that are strongly associated with infection or severe COVID-19. The researchers also identified causal factors such as smoking and high body mass index. These results come from one of the largest genome-wide association studies ever performed, which includes nearly 50,000 COVID-19 patients and two million uninfected controls. ....

Eteläuomen Läi , Mari Niemi , Landskapet Sodra Savolax , Andrea Ganna , Mark Daly , Ben Neale , Broad Institute , University Of Helsinki , Host Genetics Initiative , Institute For Molecular Medicine Finland , Genetics Initiative , Molecular Medicine Finland , Population Genetics , From Finland , East Asian , South Asian , ஆண்ட்ரியா கண்ணா , குறி டேலி , பென் நீல் , பரந்த நிறுவனம் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , தொகுப்பாளர் ஜெநெடிக்ஸ் முயற்சி , நிறுவனம் க்கு மூலக்கூறு மருந்து பின்லாந்து , ஜெநெடிக்ஸ் முயற்சி , மூலக்கூறு மருந்து பின்லாந்து , பாப்யுலேஶந் ஜெநெடிக்ஸ் ,

GWAS Reveals Multiple Host Genes Linked to Severe COVID-19 Symptoms


GWAS Reveals Multiple Host Genes Linked to Severe COVID-19 Symptoms
July 9, 2021
A global initiative founded in March 2020 called the COVID-19 Host Genomics Initiative has released a comprehensive summary of their findings, which reveal 13 loci in the human genome that are strongly associated with infection or severe COVID-19. The researchers also identified causal factors such as smoking and high body mass index. The results, published in
Nature, come from one of the largest genome-wide association studies (GWAS) ever performed, which includes nearly 50,000 COVID-19 patients and two million uninfected controls. The findings could help provide targets for future therapies and illustrate the power of genetic studies in learning more about infectious disease. ....

Mari Niemi , Landskapet Sodra Savolax , Andrea Ganna , Ben Neale , Host Genomics Initiative , Institute For Molecular Medicine Finland , Genomics Initiative , East Asian , South Asian , Molecular Medicine Finland , ஆண்ட்ரியா கண்ணா , பென் நீல் , நிறுவனம் க்கு மூலக்கூறு மருந்து பின்லாந்து , மரபியல் முயற்சி , கிழக்கு ஆசிய , தெற்கு ஆசிய , மூலக்கூறு மருந்து பின்லாந்து ,

Genetic flashpoints: Why Covid-19 hits some people harder than others


Genetic flashpoints: Why Covid-19 hits some people harder than others
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Last Updated: Jul 10, 2021, 10:54 AM IST
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Synopsis
The Nature report summarizes information from 46 studies and three meta-analyses investigating the role of human genetics in Sars-CoV-2 infections and Covid-19 severity.
ANI
Throughout the pandemic, one crucial question has perplexed scientists worldwide: Why do some people become so sick from Covid-19 while others show no symptoms at all?
Now, a peek deep into the human genome by a global initiative with more than 3,000 researchers from 25 countries is providing some answers. There are 13 locations in the genome strongly linked to either susceptibility to the virus or severe cases, the researchers reported Thursday in the journal Nature. ....

Eteläuomen Läi , Mark Daly , University Of Helsinki , Harvard University , Institute For Molecular Medicine Finland , Molecular Medicine Finland , குறி டேலி , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , ஹார்வர்ட் பல்கலைக்கழகம் , நிறுவனம் க்கு மூலக்கூறு மருந்து பின்லாந்து , மூலக்கூறு மருந்து பின்லாந்து ,