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Researchers Find SARS-CoV-2 Inhibitors

© V. Namasivayam/Pharmazeutisches Institut/Uni Bonn
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal
In order for the SARS-CoV-2 coronavirus to replicate, it relies on the main protease as a key enzyme. The virus first has its genome translated from RNA into a large protein strand. The viral main protease then cuts this protein chain into smaller pieces, from which the new virus particles are formed. The main protease is an extremely promising starting point for coronavirus drug research, says professor Dr. Christa E. Müller of the Pharmaceutical Institute a ....

Nordrhein Westfalen , Vigneshwaran Namasivayam , Maria Zyulina , Phuong Vu , V Namasivayam Pharmazeutisches Institut , Julian Breidenbach , Miriam Diett , Katharina Sylvester , Ghazl Al Hamwi , Carina Lemke , Angewandte Chemie , University Of Bonn , Institute Of The University Bonn , Transdisciplinary Research Area Life , Researchers Find , Pharmaceutical Institute , Transdisciplinary Research Area , Laura Sch , Uni Bonn , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , புோங்க் உ , ஜூலியன் ப்ரீடன்பாக் , காதரின சில்வெஸ்டர் , கரினா லெம்கீ , பல்கலைக்கழகம் ஆஃப் பொன் , நிறுவனம் ஆஃப் தி பல்கலைக்கழகம் பொன் ,

Researchers discover SARS-CoV-2 inhibitors

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IMAGE: with one of the newly developed inhibitors in the active centre. The individual domains of the protein are shown in different colours, the inhibitor in pink.
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Credit: © V. Namasivayam/Pharmazeutisches Institut/Uni Bonn
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal ....

Nordrhein Westfalen , Vigneshwaran Namasivayam , Katharina Sylvester , Dominik Thimm , Ghazl Al Hamwi , Christin Vielmuth , Jochen Bodem , Vittoria Lopez , Salahuddin Mirza , Thanigaimalai Pillaiyar , Carina Lemke , Angewandte Chemie , Robin Gedschold , Maria Zyulina , Phuong Vu , Julian Breidenbach , Miriam Diett , Nina Geiger , Pharmazeutisches Institut , Ankec Schiedel , Institute Of Virology , University Of Bonn , Institute Of The University Bonn , Transdisciplinary Research Area Life , Pharmaceutical Institute , Transdisciplinary Research Area ,

Bacterium produces pharmaceutical all-purpose weapon

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IMAGE: From left: Dr. René Richarz with an agar plate containing the bacterium, Cornelia Hermes with an extract obtained from the bacterium, and working group leader Dr. Max Crüsemann. A coralberry.
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Credit: © AG Crüsemann / University of Bonn
For some years, an active substance from the leaves of an ornamental plant has been regarded as a possible forerunner of a new group of potent drugs. So far, however, it has been very laborious to manufacture it in large quantities. That could now change: Researchers at the University of Bonn (Germany) have identified a bacterium that produces the substance and can also be easily cultivated in the laboratory. The results are published in the journal ....

Nordrhein Westfalen , Daniela Wirtz , Cornelia Hermes , Peter Mergaert , Vigneshwaran Namasivayam , Julian Patt , Stefan Kehraus , Asuka Inoue , Wiebke Hanke , Judith Alenfelder , Tsubasa Ohbayashi , German Research Foundation , Nature Communications , University Of Bonn Germany , University Of Bonn , Institute Of Pharmaceutical Biology , Pharmaceutical Biology , Professors Gabriele , Evi Kostenis , Chemistry Physics Materials Sciences , Pharmaceutical Sciences , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , டேனீலா வர்ட்ஸ் , கார்னெலியா ஹெர்ம்ஸ் , ஜூலியன் பாத்ட் , அசுகா இணௌஊே ,