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Genascence Announces Completion of Dosing and Interim Safety Data for Phase 1 Clinical Trial of GNSC-001 in Osteoarthritis

Share this article PALO ALTO, Calif., May 5, 2021 /PRNewswire/  Genascence Corporation, a clinical-stage biotechnology company developing life-changing gene therapy products for prevalent musculoskeletal diseases, today announced that dosing across all three cohorts has been completed in the Phase 1 clinical trial of GNSC-001 for the treatment of osteoarthritis (OA). GNSC-001 is an adeno-associated vector (AAV) carrying a coding sequence for interleukin-1 receptor antagonist (IL-1Ra), a potent inhibitor of interleukin-1 (IL-1) signaling. IL-1 is considered one of the key mediators involved in the pathogenesis of OA, causing inflammation as well as cartilage destruction. GNSC-001 is designed to offer long-term, sustained inhibition of IL-1 following a single injection into the affected joint.

Musculoskeletal Specialist - Auckland

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Robert J Spicer, MD is recognized by Continental Who s Who

Share this article Share this article FRISCO, Texas, March 11, 2021 /PRNewswire/  Robert J. Spicer, MD is being recognized by Continental Who s Who as a Distinguished Doctor in the field of Physical Medicine & Rehabilitation and acknowledgment of his professional excellence as a Physiatrist with Methodist Mansfield Medical Center.    (PRNewsfoto/Continental Who s Who) Board-certified Physical Medicine and Rehabilitation Physician Dr. Spicer have led a remarkable career having accrued 20 years of vast knowledge and professional experience in his field. In his current capacity, he specializes in pain management and interventional treatment combined with his specialty expertise in chronic pain, EMG/Nerve Conduction Studies, Nerve Damage, Surgery Recovery, and rehabilitation, Sports medicine, Injury, and Prosthetics. With a strong focus on rehabilitation, restoration of function and a return to a high quality of life, Dr. Spicer serves as a Physiatrist at Methodist Mansfield Me

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