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iTeos Therapeutics Announces New Preliminary Data Indicating Clinical Activity with its ...


Press release content from Globe Newswire. The AP news staff was not involved in its creation.
iTeos Therapeutics Announces New Preliminary Data Indicating Clinical Activity with its .
iTeos Therapeutics Inc.April 10, 2021 GMT
Initial data from the Phase 1 dose escalation part of the Phase 1/2a trial in adult patients with advanced solid tumors indicated EOS-448 was generally well tolerated with no dose-limiting toxicities observed
EOS-448 showed preliminary signs of clinical activity as a monotherapy, including a partial response in one pembrolizumab-resistant melanoma patient, and stable disease in multiple patients
EOS-448 reduced TIGIT
+
suppressive T regulatory cells and CD8 T cells considered to be exhausted at all tested doses, indicating engagement of FcγR, an essential component in many immune system effector functions ....

United Kingdom , United States , Waals Gewest , Mario Sznol , Joanne Jenkins Lager , Bryan Baker , Yale University , Teos Therapeutics Inc , American Association Of Cancer Research , Research Team , Company Annual Report On Form , Exchange Commission , International Dial , Clinical Development , Teos Therapeutics , American Association , Cancer Research , Annual Meeting , Inflammatory Response , Associated Research Team , Phasei Clinical Trials , Tom Van , Clinical Development Plans , Immunomodulatory Drug , Private Securities Litigation Reform Act , Annual Report ,

iTeos Therapeutics Announces New Preliminary Data Indicating Clinical Activity with its Anti-TIGIT Antibody, EOS-448, at the AACR Annual Meeting 2021


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Initial data from the Phase 1 dose escalation part of the Phase 1/2a trial in adult patients with advanced solid tumors indicated EOS-448 was generally well tolerated with no dose-limiting toxicities observed
EOS-448 showed preliminary signs of clinical activity as a monotherapy, including a partial response in one pembrolizumab-resistant melanoma patient, and stable disease in multiple patients
EOS-448 reduced TIGIT
+
suppressive T regulatory cells and CD8 T cells considered to be exhausted at all tested doses, indicating engagement of FcγR, an essential component in many immune system effector functions
Company to advance EOS-448 into combination trials with pembrolizumab and other novel agents in both checkpoint-naïve and resistant patients ....

United Kingdom , United States , Waals Gewest , Mario Sznol , Joanne Jenkins Lager , Bryan Baker , Yale University , Teos Therapeutics Inc , American Association Of Cancer Research , Research Team , Company Annual Report On Form , Exchange Commission , International Dial , Clinical Development , Teos Therapeutics , American Association , Cancer Research , Annual Meeting , Inflammatory Response , Associated Research Team , Phasei Clinical , Tom Van , Immunomodulatory Drug , Private Securities Litigation Reform Act , Annual Report , ஒன்றுபட்டது கிஂக்டம் ,

iTeos Therapeutics Inc.: iTeos Therapeutics Announces New Preliminary Data Indicating Clinical Activity with its Anti-TIGIT Antibody, EOS-448, at the AACR Annual Meeting 2021


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Initial data from the Phase 1 dose escalation part of the Phase 1/2a trial in adult patients with advanced solid tumors indicated EOS-448 was generally well tolerated with no dose-limiting toxicities observed
EOS-448 showed preliminary signs of clinical activity as a monotherapy, including a partial response in one pembrolizumab-resistant melanoma patient, and stable disease in multiple patients
EOS-448 reduced TIGIT
+
suppressive T regulatory cells and CD8 T cells considered to be exhausted at all tested doses, indicating engagement of Fc?R, an essential component in many immune system effector functions
Company to advance EOS-448 into combination trials with pembrolizumab and other novel agents in both checkpoint-naïve and resistant patients ....

United Kingdom , United States , Waals Gewest , Mario Sznol , Joanne Jenkins Lager , Bryan Baker , Yale University , Teos Therapeutics Inc , American Association Of Cancer Research , Research Team , Company Annual Report On Form , Exchange Commission , International Dial , Clinical Development , Teos Therapeutics , American Association , Cancer Research , Annual Meeting , Inflammatory Response , Associated Research Team , Phasei Clinical , Tom Van , Immunomodulatory Drug , Private Securities Litigation Reform Act , Annual Report , ஒன்றுபட்டது கிஂக்டம் ,

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