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Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it. The findings are published in the May 10, 2021, online issue of the Journal of Experimental Medicine. The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. ....
Read Time: Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it. The findings are published in the May 10, 2021, online issue of the Journal of Experimental Medicine. The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. ....
Controlling Cholesterol in Microglia Reduces Chronic Pain by Angela Mohan on May 11, 2021 at 2:57 PM Journal of Experimental Medicine. The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. It was truly gratifying to work at the intersection of two disciplines and identify the role cholesterol plays in activation of microglia immune cells of the spinal cord and regulation of chronic pain, said first author Juliana Navia-Pelaez, PhD, a postdoctoral fellow in Miller s lab. ....
Controlling cholesterol in microglia alleviates chronic pain ANI | Updated: May 11, 2021 15:45 IST Washington [US], May 11 (ANI): Researchers at the University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it. Chemotherapy can induce painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. The findings were published in an online issue of the Journal of Experimental Medicine. The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuroinflammation. Yaksh specializes i ....
University of California - San Diego Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it. The findings are published in the May 10, 2021, online issue of the Journal of Experimental Medicine. The study was a collaboration between the laboratories of senior study author Yury Miller, MD, PhD, professor of medicine, and Tony Yaksh, PhD, professor of anesthesiology and pharmacology, both at UC San Diego School of Medicine. Miller studies cholesterol metabolism and cardiovascular and neuro inflammation. Yaksh specializes in neuropathic pain. ....