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TGen identifies gene that could help prevent or delay onset of Alzheimer's disease


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PHOENIX, Ariz. April 13, 2021 Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque in the brain that leads to Alzheimer s disease, but might also prevent or delay this memory-robbing disease from developing.
ABCC1, also known as MRP1, has previously been shown in laboratory models to remove a plaque-forming protein known as amyloid beta (Abeta) from specialized endothelial cells that surround and protect the brain and cerebral spinal cord. Building on previous studies, TGen conducted a series of pre-clinical genomic laboratory experiments. Results suggest that ABCC1 not only could export Abeta out of the brain, but that increasing the expression of ABCC1 could reduce Abeta production, thus preventing, or delaying, the onset of Alzheimer s. ....

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Local Scrap Metal Shop Helps Return Stolen Cemetery Monuments


Local Scrap Metal Shop Helps Return Stolen Cemetery Monuments
Last February four monuments were stolen from Buffalo s Forest Lawn Cemetery and thanks to one local scrap metal shop, all the sculptures have been returned, and a man arrested for the crime.
One of the monuments, well-known to visitors at Forest Lawn, was a bronze statue depicting a couple waltzing.
The statues were worth more than $150,000 combined, reports the Buffalo News. Police say they recovered the stolen items, and arrested a Riverside man.
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Piscitello faces felony counts of criminal possession of stolen property, criminal mischief, grand larceny and cemetery desecration, according to the Erie County District Attorney s Office. He was arraigned in Buffalo City Court and must return June 9. ....

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