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Individual receptors caught in the act of coupling


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NEW YORK, NY A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children s Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs. 
The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of 
Nature Methods.
If two different receptors come together to form a dimer with distinctive function and pharmacology, this might allow for a new generation of drugs with greater specificity and reduced side effects, says Jonathan Javitch, MD, PhD, the Lieber Professor of Experimental Therapeutics in Psychiatry at VP&S.   ....

Jonathana Javitch , Scott Blanchard , Avikk Pati , Scottc Blanchard , Daniels Terry , Michaeld Holsey , Wesleyb Asher , Kaleeckalg Harikumar Mayo , Weill Cornell , Zhou Weill Cornell , Laurencej Miller Mayo , Jonathan Javitch , Grantt Gilmore University Of Akron , Adamw Smith University Of Akron , Meganj Kaliszewski University Of Akron , Us National Institutes Of Health , National Science Foundation , Lieber Center , Behavior Research Foundation , Mitchelld Mccauley University Of Akron , Schizophrenia Research , Scholars Program , Queensborough Community College , Jude Children Research Hospital , Hope For Depression Research Foundation , Alekhya Govindaraju New York State Psychiatric Institute ,

Individual Receptors Caught in Act of Coupling


Columbia University Irving Medical Center
A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children’s Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs.
The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of Nature Methods.
“If two different receptors come together to form a dimer with distinctive function and pharmacology, this might allow for a new generation of drugs with greater specificity and reduced side effects.” ....

Jonathana Javitch , Scott Blanchard , Avikk Pati , Scottc Blanchard , Daniels Terry , Michaeld Holsey , Wesleyb Asher , Kaleeckalg Harikumar Mayo , Weill Cornell , Zhou Weill Cornell , Laurencej Miller Mayo , Jonathan Javitch , Grantt Gilmore University Of Akron , Adamw Smith University Of Akron , Meganj Kaliszewski University Of Akron , Us National Institutes Of Health , National Science Foundation , Lieber Center , Behavior Research Foundation , Mitchelld Mccauley University Of Akron , Schizophrenia Research , Scholars Program , Queensborough Community College , Jude Children Research Hospital , Hope For Depression Research Foundation , Alekhya Govindaraju New York State Psychiatric Institute ,

Party history shared by Xi: Half a belt reminds people of the power of belief


Party history shared by Xi: Half a belt reminds people of the power of belief
chinadaily.com.cn |
Updated: 2021-04-21 06:40
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Editor s note: This year marks the centenary of the Communist Party of China. To learn more about the history of the ruling party of China, we will publish a series of inspiring stories shared by President Xi Jinping, who is also general secretary of the CPC Central Committee. Here s the third story, about half a belt left by Red Army soldiers during the Long March.
Half a belt reminds people of the power of belief
Half a belt left by Red Army soldiers during the Long March. [File photo/Xinhua] ....

Zhou Guangcai , National Museum Of China , Party Of China , Red Army , Central Committee , Communist Party , President Xi Jinping , Long March , Chairman Mao , National Museum , தேசிய அருங்காட்சியகம் ஆஃப் சீனா , கட்சி ஆஃப் சீனா , சிவப்பு இராணுவம் , மைய குழு , கம்யூனிஸ்ட் கட்சி , நீண்டது அணிவகுப்பு , தலைவர் மாவோ , தேசிய அருங்காட்சியகம் ,

Seeking the perfect gift or self-care treat? Enter Croatian-made, eco-friendly soaps by Jou Jou


Seeking the perfect gift or self-care treat? Enter Croatian-made, eco-friendly soaps by Jou jou
By Lara Rasin
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Jou Jou products are made at the intersection of love for natural handmade products - and love for nature and the environment.
The product range includes splendid soaps, bath bombs, and bath teas made by the Zagreb-based company - and all are sure to delight anyone who gets their hands on them!
These imaginative soaps are always handmade with only the highest quality olive, coconut, rapeseed and castor oils and shea butter - with the addition of clay and plant extracts. At Jou Jou, sustainable soaps are created in small series, right when inspiration hits. As such, each is different and none can be recreated identically. Along with soaps Jou Jou offers a number of unique bath bombs and bath teas to soak in, too. There s something for everyone here - whether you re looking for a calming chamomile tea for the body or an energizing active c ....

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