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Illuminating Mechanisms of GPCR Activation

GPCR-targeting drugs make up around a third of those approved by the FDA, yet often come with side effects. New research into the mechanisms of GPCR activation could help design drugs to prevent side effects. ....

Jonathana Javitch , Scottc Blanchard , Wesleyb Asher , Jude Children Research Hospital , Department Of Psychiatry At Columbia , York State Psychiatric Institute , Drug Administration , Lieber Professor , Experimental Therapeutics , Columbia University Vagelos College , New York State Psychiatric , Jude Children , Research Hospital ,

Scientists Illuminate Mechanism of Common Drug Target

Scientists Illuminate Mechanism of Common Drug Target
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United States , Jonathana Javitch , Robertj Lefkowitz Duke , Scottc Blanchard , Alekhya Govindaraju , Huang Duke , Daniels Terry , Wesleyb Asher , Asuka Inoue Tohoku University , University Of California , Behavior Research Foundation , Department Of Psychiatry At Columbia , Wonjo Jang Augusta University , Hope Depression Research Foundation , Nevina Lambert Augusta University , Vsevolodv Gurevich Vanderbilt University , Jude Children Research Hospital , Alemw Kahsai Duke University , Drug Administration , Lei Shi National Institute On Drug Abuse , Molecule Imaging Center At St , York State Psychiatric Institute , Bing Xie National Institute On Drug Abuse , Phrma Foundation , Howard Hughes Medical Institute , Lieber Professor ,

Individual receptors caught in the act of coupling

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NEW YORK, NY A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children s Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs.
The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of
Nature Methods.
If two different receptors come together to form a dimer with distinctive function and pharmacology, this might allow for a new generation of drugs with greater specificity and reduced side effects, says Jonathan Javitch, MD, PhD, the Lieber Professor of Experimental Therapeutics in Psychiatry at VP&S. ....

Jonathana Javitch , Scott Blanchard , Avikk Pati , Scottc Blanchard , Daniels Terry , Michaeld Holsey , Wesleyb Asher , Kaleeckalg Harikumar Mayo , Weill Cornell , Zhou Weill Cornell , Laurencej Miller Mayo , Jonathan Javitch , Grantt Gilmore University Of Akron , Adamw Smith University Of Akron , Meganj Kaliszewski University Of Akron , Us National Institutes Of Health , National Science Foundation , Lieber Center , Behavior Research Foundation , Mitchelld Mccauley University Of Akron , Schizophrenia Research , Scholars Program , Queensborough Community College , Jude Children Research Hospital , Hope For Depression Research Foundation , Alekhya Govindaraju New York State Psychiatric Institute ,

Individual Receptors Caught in Act of Coupling

Columbia University Irving Medical Center
A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children’s Research Hospital captures movies of receptors on the surface of living cells in unprecedented detail and could pave the way to a trove of new drugs.
The researchers used the technique to zoom in on individual receptor proteins on the surface of living cells to determine if the receptors work solo or come together to work as pairs. This work appeared in the April issue of Nature Methods.
“If two different receptors come together to form a dimer with distinctive function and pharmacology, this might allow for a new generation of drugs with greater specificity and reduced side effects.” ....

Jonathana Javitch , Scott Blanchard , Avikk Pati , Scottc Blanchard , Daniels Terry , Michaeld Holsey , Wesleyb Asher , Kaleeckalg Harikumar Mayo , Weill Cornell , Zhou Weill Cornell , Laurencej Miller Mayo , Jonathan Javitch , Grantt Gilmore University Of Akron , Adamw Smith University Of Akron , Meganj Kaliszewski University Of Akron , Us National Institutes Of Health , National Science Foundation , Lieber Center , Behavior Research Foundation , Mitchelld Mccauley University Of Akron , Schizophrenia Research , Scholars Program , Queensborough Community College , Jude Children Research Hospital , Hope For Depression Research Foundation , Alekhya Govindaraju New York State Psychiatric Institute ,