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Red blood cell alterations contribute to lupus

The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by. ....

United States , Weill Cornell , Jim Schnabel , Astra Zeneca , Simone Caielli , Lupus Research Alliance , Drukier Institute , Research Translation , National Institute Of Arthritis , Ira Drukier Institute For Children Health , Department Of Pediatrics At Weill Cornell Medicine , Virginia Pascual , Drukier Director , Ira Drukier Institute , Ronay Menschel Professor , National Institute , Skin Diseases , Cornell University , United States , Autoimmune Disease , Immune Cells , ஒன்றுபட்டது மாநிலங்களில் , வெயில் கார்னெல் , ஜிம் ஶ்ந்யாபெல் , அஸ்ட்ரா ஸெநெக , லூபஸ் ஆராய்ச்சி கூட்டணி ,

Study reveals a cause of heart damage in COVID-19 patients

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Study reveals a cause of heart damage in COVID-19 patients
The heart damage seen in many severely ill COVID-19 patients results in part from infection-activated immune cells called macrophages, which infiltrate the heart and secrete cell-damaging chemicals, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian, Icahn School of Medicine at Mt. Sinai and Columbia University Irving Medical Center. The research identifies new potential treatments for COVID-19 patients as well as describes a model system for further studies and drug screening.
Dr. Liuliu Yang/Weill Cornell Medicine
Confocal image of heart autopsy sample of a COVID-19 patient. The image shows the damaged structure of cardiomyocytes (red) and increased expression of chemokine, CCL2 (green), which recruits macrophages that further damage heart tissue. ....

Weill Cornell , Todd Evans , Jim Schnabel , Liuliu Yang Weill Cornell , Shuibing Chen , Robert Schwartz , Columbia University Irving Medical Center , Division Of Gastroenterology , Drug Administration , Icahn School Of Medicine At Mt , Circulation Research , Weill Cornell Medicine , Icahn School , Columbia University Irving Medical , Kilts Family Associate Professor , வெயில் கார்னெல் , டாட் எவன்ஸ் , ஜிம் ஶ்ந்யாபெல் , ராபர்ட் ஸ்க்வார்ட்ஸ் , கொலம்பியா பல்கலைக்கழகம் இவிஂக் மருத்துவ மையம் , பிரிவு ஆஃப் இரைப்பை குடல் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ம்த் , சுழற்சி ஆராய்ச்சி , வெயில் கார்னெல் மருந்து , இக்ஹ்ன் பள்ளி , கொலம்பியா பல்கலைக்கழகம் இவிஂக் மருத்துவ ,

Tumor microenvironment helps aggressive lymphomas

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Tumor microenvironment helps aggressive lymphomas
The environment surrounding the cancerous cells of a lymphoma tumor has a strong influence on the progression of these blood-cell cancers and their responses to therapies, according to a new study by Weill Cornell Medicine investigators.
Measuring this molecular and cellular environment, or “microenvironment,” appears to represent a new type of precision-medicine approach to lymphoma classification and treatment.
CoRus13/Creative Commons
Diffuse large B-cell lymphoma.
The team analyzed the patterns of gene activity in tumor samples taken from the lymph nodes of thousands of lymphoma patients. They found that the cells within these tumors, which include both cancer cells and healthy cells, produce molecules that collectively constitute a distinct microenvironment for the tumors, influencing their biology and growth. ....

United States , Weill Cornell , Jim Schnabel , Leandro Cerchietti , John Leonard , American Association For Cancer Research , Division Of Hematology , Weill Cornell Medicine , Creative Commons , Cancer Discovery , American Association , Edward Meyer Cancer Center , Giorgio Inghirami , Cornell University , Irna Sequencing , Patient Outcomes , Cancer Research , ஒன்றுபட்டது மாநிலங்களில் , வெயில் கார்னெல் , ஜிம் ஶ்ந்யாபெல் , ஜான் லியோனார்ட் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , பிரிவு ஆஃப் ஹீமாட்டாலஜி , வெயில் கார்னெல் மருந்து , படைப்பு காமன்ஸ் , புற்றுநோய் கண்டுபிடிப்பு ,

Weill Cornell researchers detect key flaw in brain modeling

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Weill Cornell researchers detect key flaw in brain modeling
A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.
Lis Lab/Provided
Induced brain microvascular endothelial cells (IBMECs), top, cultured in 3D assume an epithelial organoid structure and express the epithelial cell marker EPCAM (purple). When they are reprogrammed by overexpression of ETV2, ERG and FLI1, they lose EPCAM expression, acquire vascular markers VE-Cad (red) and PECAM1 (green) and are able to fulfill the function of endothelial cells – forming blood vessels, shown in bottom image. ....

Tyler Lu , Jim Schnabel , Ronaldo Perelman , David Redmond , Columbia University Irving Medical Center , Claudia Cohen Center , Proceedings Of The National Academy Sciences , Ansary Stem Cell Institute , Lis Lab Provided , Memorial Sloan Kettering Cancer Center , Weill Cornell Medicine , Columbia University Irving Medical , National Academy , Regenerative Medicine , Weill Cornell , Reproductive Medicine , Cornell University , Computational Biology , Drug Development , Blood Vessels , Brain Cancer , Stem Cells , டைலர் லு , ஜிம் ஶ்ந்யாபெல் , ரொனள்டோ பெரல்மேன் , டேவிட் ரெட்மண்ட் ,