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Gene editor injected into the body treats disease

Gene editor injected into the body treats disease
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Jocelyn Kaiser , ஜாஸ்லைந் கைசர் ,

Tumors find many ways to evade groundbreaking cancer drug


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Patients with lung cancer (shown here) developed a wide array of resistance mechanisms to a KRAS inhibitor drug.
SPL/Science Source
Tumors find many ways to evade groundbreaking cancer drug
Jun. 23, 2021 , 5:45 PM
Researchers were ecstatic 2 years ago when, after decades of effort, they devised drugs that could block a tumor-promoting protein in cancer patients called KRAS, which previously seemed impervious to treatment. But many of these KRAS inhibitors the first of which was approved by U.S. regulators in May quickly lost their luster, like other targeted cancer drugs: Most patients’ tumors resumed growing after a few months, as their cancer cells became resistant to the inhibitors. Now, a study finds that the roots of this resistance are surprisingly complex, with tumors using an array of escape routes to evade the attack on KRAS. ....

United States , San Francisco , Mark Awad , Kevan Shokat , Andrew Aguirre , Jocelyn Kaiser , Colin Lindsay , University Of California , University Of Manchester , Dana Farber Cancer Institute , Science Source , New England Journal , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , குறி அவாட் , கெவன் ஷோகாட் , ஜாஸ்லைந் கைசர் , கொலின் லிண்ட்சே , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் மான்செஸ்டர் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , அறிவியல் மூல , புதியது இங்கிலாந்து இதழ் ,