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PTSD seems to be tied to gene expression changes in the brain

PTSD seems to be tied to gene expression changes in the brain
Still a ways to go, but it’s an important step.
Image via Pixabay.
Post-mortem analysis of the brain tissue of patients who had been diagnosed with PTSD are helping us better understand the condition. There’s still a lot we can’t make sense of with PTSD, including why women seem to be more susceptible to it, and whether an impaired immune system plays a part.
The brain of the matter
The analysis was led by researchers from the Yale University, finding differences in gene expression patterns between patients with PTSD and healthy people in four regions of the prefrontal cortex (PFC). The PFC is associated with higher cognitive functions. These differences affected two types of cells in patients: interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report. ....

Matthew Girgenti , John Krystal , Yale University , Yale Department Of Psychiatry , Yale Department , ஜான் கிரிஸ்டல் , யேல் பல்கலைக்கழகம் , யேல் துறை ஆஃப் மனநல மருத்துவம் , யேல் துறை ,

Brain tissue yields clues to causes of PTSD

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A post-mortem analysis of brain tissue from people who had been diagnosed with post-traumatic stress disorder (PTSD) may help explain enduring mysteries about the disorder, such as why women are more susceptible to it and whether a dampened immune system response plays a role in dealing with stress, a team headed by Yale University researchers has found.
The analysis of gene expression patterns in brain tissue located in four regions of the prefrontal cortex areas of the brain associated with higher cognitive function and executive control revealed distinct differences in those who had been diagnosed with PTSD and those who had not. Major differences in gene activity particularly affected two cell types in PTSD patients interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal ....

Yale John Krystal , Matthew Friedman , Matthew Girgenti , Ronald Duman , Robertl Mcneil Jr , Hongyu Zhao , Yale University , Professor Of Translational Research , Brain Bank , Us Department Of Veterans , Yale Department Of Psychiatry , Dartmouth University , White River Junction Va Medical Center , Yale Department , John Krystal , Translational Research , Veterans Affairs Based , White River Junction , யேல் ஜான் கிரிஸ்டல் , மேத்யூ ப்ரைட்மேன் , ரொனால்ட் டுமன் , யேல் பல்கலைக்கழகம் , ப்ரொஃபெஸர் ஆஃப் மொழிபெயர்ப்பு ஆராய்ச்சி , மூளை வங்கி , எங்களுக்கு துறை ஆஃப் வீரர்கள் , யேல் துறை ஆஃப் மனநல மருத்துவம் ,

Common plastics chemicals linked to ADHD symptoms – phthalate

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They found a significant positive association between phthalate exposure and ADHD, meaning that the higher the concentration of phthalate metabolites in the urine, the worse the ADHD symptoms and/or test scores.
Disney school supplies loaded with toxic phthalates, next to petitions signed by 65,000 parents across the country (Photo credit: CHEJ)

Are phthalates really safe for children?
Philadelphia, PA, 19 November 2009 – Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items. Studies to date on phthalates have been inconsistent, with some linking exposure to these chemicals to hormone disruptions, birth defects, asthma, and reproductive problems, while others have found no significant association between exposure and adverse effects. ....

United States , Ralph Turchiano , Yun Chul Hong , John Krystal , Us Centers For Disease , Biological Psychiatry , Disease Control , National Report , Human Exposure , Environmental Chemicals , ஒன்றுபட்டது மாநிலங்களில் , யுன் சுல் ஹாங் , ஜான் கிரிஸ்டல் , எங்களுக்கு மையங்கள் க்கு நோய் , உயிரியல் மனநல மருத்துவம் , நோய் கட்டுப்பாடு , தேசிய அறிக்கை , மனிதன் நேரிடுவது , சுற்றுச்சூழல் இரசாயனங்கள் ,