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Brain tissue analysis may help explain enduring mysteries about PTSD

Brain tissue analysis may help explain enduring mysteries about PTSD
A post-mortem analysis of brain tissue from people who had been diagnosed with post-traumatic stress disorder (PTSD) may help explain enduring mysteries about the disorder, such as why women are more susceptible to it and whether a dampened immune system response plays a role in dealing with stress, a team headed by Yale University researchers has found.
The analysis of gene expression patterns in brain tissue located in four regions of the prefrontal cortex areas of the brain associated with higher cognitive function and executive control revealed distinct differences in those who had been diagnosed with PTSD and those who had not. Major differences in gene activity particularly affected two cell types in PTSD patients interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal ....

Yale John Krystal , Matthew Girgenti , Robertl Mcneil Jr , Emily Henderson , Yale University , Research Scientist , Professor Of Translational Research , Yale Department Of Psychiatry , Yale Department , Study Lead , John Krystal , Translational Research , யேல் ஜான் கிரிஸ்டல் , எமிலி ஹென்டர்சன் , யேல் பல்கலைக்கழகம் , ஆராய்ச்சி விஞ்ஞானி , ப்ரொஃபெஸர் ஆஃப் மொழிபெயர்ப்பு ஆராய்ச்சி , யேல் துறை ஆஃப் மனநல மருத்துவம் , யேல் துறை , படிப்பு வழி நடத்து , ஜான் கிரிஸ்டல் , மொழிபெயர்ப்பு ஆராய்ச்சி ,

Brain tissue yields clues to causes of PTSD

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A post-mortem analysis of brain tissue from people who had been diagnosed with post-traumatic stress disorder (PTSD) may help explain enduring mysteries about the disorder, such as why women are more susceptible to it and whether a dampened immune system response plays a role in dealing with stress, a team headed by Yale University researchers has found.
The analysis of gene expression patterns in brain tissue located in four regions of the prefrontal cortex areas of the brain associated with higher cognitive function and executive control revealed distinct differences in those who had been diagnosed with PTSD and those who had not. Major differences in gene activity particularly affected two cell types in PTSD patients interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal ....

Yale John Krystal , Matthew Friedman , Matthew Girgenti , Ronald Duman , Robertl Mcneil Jr , Hongyu Zhao , Yale University , Professor Of Translational Research , Brain Bank , Us Department Of Veterans , Yale Department Of Psychiatry , Dartmouth University , White River Junction Va Medical Center , Yale Department , John Krystal , Translational Research , Veterans Affairs Based , White River Junction , யேல் ஜான் கிரிஸ்டல் , மேத்யூ ப்ரைட்மேன் , ரொனால்ட் டுமன் , யேல் பல்கலைக்கழகம் , ப்ரொஃபெஸர் ஆஃப் மொழிபெயர்ப்பு ஆராய்ச்சி , மூளை வங்கி , எங்களுக்கு துறை ஆஃப் வீரர்கள் , யேல் துறை ஆஃப் மனநல மருத்துவம் ,