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Mass spectrometry: An important tool to unravel mechanisms underlying Huntington's disease


Mass spectrometry: An important tool to unravel mechanisms underlying Huntington s disease
Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington s disease (HD), alongside the increased availability of cell and animal models of the disease.
This review, published in the
Journal of Huntington s Disease, brings together and recaps data from major published mass spectrometry studies undertaken in HD research over the last 20 years, identifying important changes that occur in HD. The authors encourage researchers to make greater use of these studies to accelerate the development of new treatments.
HD is a rare neurodegenerative disorder caused by the aberrant expression of mutant Huntingtin (HTT) protein containing an expanded polyglutamine tract. Mass spectrometry is a technique that has existed for over a century to measure the mass-to-charge ratio of ions, however, proteins in complex mix ....

United States , Kimberlyb Kegel Gleason , Connor Seeley , Emily Henderson , Massgeneral Institute For Neurodegenerative Disease , Department Of Neurology , Laboratory Of Cellular Neurobiology , Study Co , Massgeneral Institute , Neurodegenerative Disease , Massachusetts General Hospital , Study Co Author , Cellular Neurobiology , Massachusetts General , ஒன்றுபட்டது மாநிலங்களில் , இணைப்பான் சீலி , எமிலி ஹென்டர்சன் , துறை ஆஃப் நரம்பியல் , படிப்பு இணை , வெகுஜன நிறுவனம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , படிப்பு இணை நூலாசிரியர் , செல்லுலார் நரம்பியல் , மாசசூசெட்ஸ் ஜநரல் ,