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AI-designed serotonin sensor may help scientists study sleep and mental health

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IMAGE: NIH BRAIN Initiative-funded scientists used artificial intelligence to help redesign a nutrient grabbing, Venus flytrap-shaped bacterial protein into a highly sensitive serotonin sensor. Here the sensor captured for the first.
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Credit: Courtesy of Tian lab. University of California Davis School of Medicine.
Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons. In an article in
Cell, National Institutes of Health-funded researchers described how they used advanced genetic engineering techniques to transform a bacterial protein into a new research tool that may help monitor serotonin transmission with greater fidelity than current methods. Preclinical experiments, primarily in mice, showed that the sensor could detect subtle, real-time changes in brain serotonin levels during s ....

United States , University Of California Davis , Johnj Ngai , Lorenl Looger , Edmund Ned Talley , Viviana Gradinaru , National Institute On Drug Abuse , Howard Hughes Medical Institute Janelia Research Campus , Vector Engineering Research , National Institute On , University Of California Davis School Medicine , National Institute Of Biomedical Imaging , National Institute Of Mental Health , National Eye Institute , Mistletoe Foundation , National Institute Of Neurological Disorders , Human Development , Us Department Of Energy Contract No , National Center , Us Department Of Health , Human Services , National Institutes Of Health , Intramural Research Programs , Brain Research , Cellular Neuroscience Of The Chen Institute , National Institute On Deafness ,

FEFU scientists suggest reconsidering existing treatment protocol for severe spinal cord trauma

FEFU scientists suggest reconsidering existing treatment protocol for severe spinal cord trauma
Scientists from Far Eastern Federal University (FEFU) together with leading international experts suggest reconsidering the existing treatment protocol for severe spasticity, one of the main complications after spinal cord injury with partial spinal cord disruption. Spasticity aggravates a patient s state and dramatically reduces the prospects of rehabilitation. The new treatment protocol has been run at FEFU Medical Center. A related article was published in the
Progress in Brain Research journal.
A team from FEFU developed a protocol helping to learn the eligibility of disabled patients with spinal cord trauma and severe spasticity for the implantation of a spinal cord stimulator or an Intrathecal Baclofen infusion pump. For the first time, these alternative methodologies were compared in two experimental groups. ....

Igor Bryukhovetskiy , Emily Henderson , Eastern Federal University , Progress In Brain Research , Head Of The Laboratory Molecular , Department Of Fundamental Medicine , School Of Biomedicine , Far Eastern Federal University , Brain Research , Intrathecal Baclofen , Baclofen Therapy , Cellular Neurobiology , Fundamental Medicine , எமிலி ஹென்டர்சன் , கிழக்கு கூட்டாட்சியின் பல்கலைக்கழகம் , ப்ரோக்ரெஸ் இல் மூளை ஆராய்ச்சி , தலை ஆஃப் தி ஆய்வகம் மூலக்கூறு , துறை ஆஃப் அடிப்படை மருந்து , இதுவரை கிழக்கு கூட்டாட்சியின் பல்கலைக்கழகம் , மூளை ஆராய்ச்சி , செல்லுலார் நரம்பியல் , அடிப்படை மருந்து ,

FEFU scientists suggest using neuromodulation to treat patients with spinal cord injuries

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IMAGE: Artur Biktimirov, a neurosurgeon, at FEFU National Technological Initiative center for Neurotechnology, Virtual reality (VR), and Augmented reality (AR).
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Credit: FEFU press office
Scientists from Far Eastern Federal University (FEFU) together with leading international experts suggest reconsidering the existing treatment protocol for severe spasticity, one of the main complications after spinal cord injury with partial spinal cord disruption. Spasticity aggravates a patient s state and dramatically reduces the prospects of rehabilitation. The new treatment protocol has been run at FEFU Medical Center. A related article was published in the
Progress in Brain Research journal.
A team from FEFU developed a protocol helping to learn the eligibility of disabled patients with spinal cord trauma and severe spasticity for the implantation of a spinal cord stimulator or an Intrathecal Baclofen infusion pump. For the first time, th ....

Igor Bryukhovetskiy , Artur Biktimirov , Eastern Federal University , Progress In Brain Research , Head Of The Laboratory Molecular , National Technological Initiative Center , Centers No , School Of Biomedicine , Russian Venture Company , Far Eastern Federal University , Brain Research , Intrathecal Baclofen , Baclofen Therapy , Cellular Neurobiology , Fundamental Medicine , Technological Initiative , Technological Initiative Center , Granting Subsidies , State Support , கிழக்கு கூட்டாட்சியின் பல்கலைக்கழகம் , ப்ரோக்ரெஸ் இல் மூளை ஆராய்ச்சி , தலை ஆஃப் தி ஆய்வகம் மூலக்கூறு , தேசிய தொழில்நுட்ப முயற்சி மையம் , மையங்கள் இல்லை , ரஷ்ய துணிகர நிறுவனம் , இதுவரை கிழக்கு கூட்டாட்சியின் பல்கலைக்கழகம் ,