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Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion. ....

Johnfx Diffley , Jocelyn Solis Moreiraapr , Jocelyn Solis Moreira , Chromosome Replication Laboratory , Small Molecule Inhibitors , Image Credit , Sars Cov 2 , Corona Virus , In Vitro , Mammalian Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , படம் கடன் , கொரோனா வைரஸ் , இல் விட்ரோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Screening for SARS-CoV-2 non-structural protein 14 inhibitors


Screening for SARS-CoV-2 non-structural protein 14 inhibitors
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome generates 16 distinct non-structural proteins (nsp) that constitute the enzymes and accessory proteins responsible for virus replication once inside a host cell. These protein complexes produce and cap RNA strands that will go on to be translated by the host machinery. Capping the RNA in a manner that is recognized as similar to endogenous mRNA ensures compatibility, lessens RNA degradation rates and lowers the probability of triggering an immune response in the host cell.
In a paper recently uploaded to the preprint server
et al. (April 8
th, 2021), inhibitors of one essential SARS-CoV-2 non-structural protein are explored, with four compounds, in particular, identified as potential antiviral leads that exhibit synergistic effects with antiviral drug remdesivir. ....

Diffleyet Al , Michael Greenwood , Small Molecule Inhibitors , Image Credit , Sars Cov 2 , Structural Protein , Antiviral Drug , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , படம் கடன் , கட்டமைப்பு ப்ரோடீந் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,