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Cancer-killing virus therapy shows promise against inoperable skin cancers


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Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed.
The drug combination is among the first, researchers say, to demonstrate the potential value of a live common cold virus, a coxsackievirus, to infect and kill cancer cells.
The Phase I study, led by a researcher at NYU Langone Health and its Perlmutter Cancer Center, is also among the first to show how such oncolytic viruses can safely boost the action of widely used cancer therapies that help the body s immune defense system detect and kill cancer cells. Currently, such immunotherapies are only effective in shrinking melanoma tumors in just over a third of patients who receive them. ....

United States , New South Wales , Dana Farber Cancer Institute , Edwin Zambrano Acosta , Bernard Fox , Cai Wu , David March , Janice Mehnert , Daniel Medina , Marisa Palmeri , Casey Imbergamo , Joshua Vieth At Rutgers University , Langone Health , John Wayne Cancer Institute In Santa Monica , Ann Silk At Dana Farber Cancer Institute , Carmen Ballesteros Merino At Providence Portland Medical Center , American Association For Cancer Research , Grossman School Of Medicine , Andrew Zloza At Rush University , Gabrail Cancer Center , Rutgers Cancer Institute , Perlmutter Cancer Center , Seymour Fein At Seattle Cancer Care Alliance , American Association , Cancer Research , New Brunswick ,