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Cancer-killing treatment using a common cold virus offers hope to patients with inoperable tumors


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Our initial study results are very promising and show that this oncolytic virus injection, a modified coxsackievirus, when combined with existing immunotherapy is not only safe but has the potential to work better against melanoma than immunotherapy alone, said Dr. Janice Mehnert, the study s senior investigator and a medical oncologist, in a statement.
Mehnert cautioned that further testing, which is already underway, would have to prove successful before the combination treatment could become a standard of care, or go-to therapy, for patients with advanced melanoma, meaning melanoma that has spread to other parts of the body.
She added that the next phase of clinical trials will involve patients with melanoma that has become widespread, as well as in patients whose tumors, if shrunken by the drug combination, could be more easily removed by surgery. ....

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Cancer treatment using a common cold virus offers hope to patients


Cancer treatment using a common cold virus offers hope to patients
Keith Griffith For Dailymail.com
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A new study using one of the viruses responsible for the common cold has shown promise in treating advanced skin cancer that could not be treated with surgery.
The results of the Phase 1 study, led by a researcher at NYU Langone Health and its Perlmutter Cancer Center, were announced on Friday, adding to the growing body of research into oncolytic viruses.
The clinical trial utilized live coxsackievirus, one of the many viruses that can cause a common cold, in combination with pembrolizumab, an immunotherapy drug known as pembro or Keytruda. ....

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Cancer Therapy Using Common Cold Virus Shows Promise Against Inoperable Skin Cancers


Oxford Pauses Trial of AstraZeneca Covid-19 Vaccine in Children and Teenagers
While surgical interventions can enable the treatment of certain forms of skin cancer, there are few that cannot be operated upon. Offering hope to individuals suffering from the latter, a new study has reported the effective and safe action of a new combination drug therapy involving a virus against tumors in patients ailing from advanced inoperable skin cancer.
The novel drug combination used in the Phase I study illustrated the ability of a live common cold-causing virus, a coxsackievirus, to invade and destroy cancer cells. It is also among the first to demonstrate the capacity of oncolytic viruses that infect and kill cancer cells in safely bolstering the efficacy of generally employed cancer therapies that aid the immune system in seeking and neutralizing cancer cells.  ....

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