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Scientists Identify Mechanism Linking Exercise with Bone Strength and Immunity


Scientists Identify Mechanism Linking Exercise with Bone Strength and Immunity
February 25, 2021
Source: Ekaterina Kuznetsova/Unsplash
Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified a new mechanism by which exercise strengthens bones and immune function. Their studies in laboratory-grown cells and in mice, highlighted a specialized bone marrow niche where new bone and immune cells are produced, and demonstrated that movement-induced stimulation is required for the maintenance of the niche and the bone and immune-forming cells that it contains. They suggest the results point to the potential development of new therapeutic strategies that might increase bone formation and immune responses, particularly in the elderly. ....

Bo Shen , Sean Morrison , Children Medical Center Research Institute , Howard Hughes Medical Institute , Medical Center Research Institute , போ ஷென் , சீன் மோரிசன் , குழந்தைகள் மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் ,

Impact of Running Reaches Marrow to Spark Bone Growth in Mice


A study offers a new explanation for how exercise strengthens bones and the immune system.
Mar 2, 2021
ABOVE: Deep imaging of bone marrow in a mouse femur showing that osteolectin-expressing cells (red) are around arterioles (white) but not sinusoids (green), a different type of blood vessel in the bone marrow.
CHILDREN’S MEDICAL CENTER RESEARCH INSTITUTE AT UT SOUTHWESTERN
Mechanical forces from running and walking that are transmitted along blood vessels in marrow induce the growth of new bone and immune cells in mice, scientists reported in
Nature on February 24. The study is the first to demonstrate that mechanical forces can influence cellular growth and differentiation in the bone marrow, according to the authors, and provides a possible new explanation for how exercise strengthens bones and the immune system. ....

Siddaraju Boregowda , Bo Shen , Sean Morrison , David Ferguson , Scripps Research Institute , Children Medical Center Research Institute , Michigan State University , Medical Center Research Institute , போ ஷென் , சீன் மோரிசன் , டேவிட் ஃபெர்குசன் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம் , குழந்தைகள் மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் , மிச்சிகன் நிலை பல்கலைக்கழகம் , மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் ,