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Ludwig Cancer Research study shows how certain macrophages dampen anti-tumor immunity


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IMAGE: Ludwig Memorial Sloan Kettering s investigators Taha Merghoub, Jedd Wolchok and assistant attending physician Andrew Chow.
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Credit: Ludwig Cancer Research
JUNE 10, 2021, NEW YORK - A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system s cancer-killing CD8+ T cells.
Reported in the current issue of
Cancer Cell and led by Ludwig investigators Taha Merghoub and Jedd Wolchok at Memorial Sloan Kettering (MSK) and Charles Rudin of MSK, the study shows that cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), a molecule that they surprisingly found on the surface of highly activated, cytotoxic and proliferative CD8+ T-cells. ....

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Oscar's revenue is spiking, but it's still losing money


Oscar s revenue is spiking, but it s still losing money
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Oscar Health s first quarter financial results, its first since a $1.4 billion IPO in March, have the tech-focused insurance company s cheerleaders celebrating a game point scored. But skeptics point to a glaring $87.4 million loss as a reminder that Oscar has yet to turn a profit, seven years in.
The SoHo-based company on Thursday reported $369 million in revenue during the first quarter, which ran from January through the end of March, compared with $88 million in the first quarter of 2020. Its $87.4 million net loss during the quarter was down from a net loss just under $97 million in the first quarter of 2020. ....

United States , City Of , United Kingdom , Charles Rudin , Shuan Sim , Lenox Hill , Sarah Vinson , Sloan Kettering , Geoff Fatzinger , Ricky Goldwasser , Maya Kaufman , Mario Schlosser , Denis Corin , Catholic Health Mercy Hospital , Morgan Stanley , Department Of Defense , Rockville Centre , Oscar Health , Lung Cancer Research , Ning Zhao Family Foundation , Lorio Psych Group , Clover Health , Aedesius Holdings , Mother Cabrini Health Foundation , Alzheimer Drug Discovery Foundation , Memorial Sloan Kettering Cancer Center ,