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Surprise finding shows that neutrophils can be key antitumor weapons

Surprise finding shows that neutrophils can be key antitumor weapons
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Taha Merghoub , Daniel Hirschhorn , Presbyterian Weill Cornell Medical Center , Meyer Cancer Center , Ludwig Collaborative Laboratory , Edward Meyer Cancer Center , Herman Sokol Professor Of Oncology Research , Herman Sokol Professor , Oncology Research , Weill Cornell Medicine , Ludwig Collaborative , Jedd Wolchok , Meyer Director , Weill Cornell Medical , Weill Cornell ,

Surprise finding shows that neutrophils can be key antitumor weapons - ScienceDaily

Surprise finding shows that neutrophils can be key antitumor weapons - ScienceDaily
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Taha Merghoub , Daniel Hirschhorn , Presbyterian Weill Cornell Medical Center , Ludwig Collaborative Laboratory , Meyer Cancer Center , Edward Meyer Cancer Center , Herman Sokol Professor Of Oncology Research , Herman Sokol Professor , Oncology Research , Weill Cornell Medicine , Ludwig Collaborative , Jedd Wolchok , Meyer Director , Weill Cornell Medical , Weill Cornell ,

Ludwig Cancer Research study shows how certain macrophages dampen anti-tumor immunity


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IMAGE: Ludwig Memorial Sloan Kettering s investigators Taha Merghoub, Jedd Wolchok and assistant attending physician Andrew Chow.
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Credit: Ludwig Cancer Research
JUNE 10, 2021, NEW YORK - A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system s cancer-killing CD8+ T cells.
Reported in the current issue of
Cancer Cell and led by Ludwig investigators Taha Merghoub and Jedd Wolchok at Memorial Sloan Kettering (MSK) and Charles Rudin of MSK, the study shows that cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), a molecule that they surprisingly found on the surface of highly activated, cytotoxic and proliferative CD8+ T-cells. ....

United States , Charles Rudin , Taha Merghoub , Andrew Chow , Sloan Kettering , Danielk Ludwig , Us National Cancer Institute , Weill Cornell Medical College , A Ludwig Cancer Research , Ludwig Cancer Research , Emerald Foundation , Ludwig Center , Ludwig Collaborative Laboratory , Ludwig Collaborative Swim Across America Laboratory , Parker Institute For Cancer Immunotherapy , Us Department Of Defense , American Cancer Society , Cancer Cell , Jedd Wolchok , Memorial Sloan Kettering , Ludwig Collaborative , Swim Across America Laboratory , Weill Cornell Medical , Clinical Investigation , Parker Institute , Swim Across America ,