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14 have been identified to promote cervical cancer progression, suggesting the important role of circRNAs in cervical cancer tumorigenesis. As for circ 0003221 (also known as circPTK2, chr8:141856358–141900868), it has been demonstrated to be overexpressed in cervical cancer cells. 15 Nevertheless, the role of circ 0003221 in cervical cancer remains largely unclear. Large evidence has shown that circRNAs can serve as competing endogenous RNAs (ceRNAs), also known as microRNA (miRNA) sponges, via competitively binding to miRNA response elements, thereby regulating the expression of downstream target genes. 16,17 Based on this regulation, circRNAs can function as miRNA sponges to regulate the expression of target genes, forming a regulatory circRNA-miRNA-mRNA network. MiR-758 has been identified to serve as a tumor-suppressing miRNA in cervical cancer. ....
 Citizens of Sardis City gathered together last weekend under the new pavilion at Sardis City Park to celebrate Independence Day and honor fallen veteran Roscoe Smith Jr., who was killed during World War II. Before being deployed in 1944 as a U.S. Marine, Roscoe Smith married his high school sweetheart, Pauline Lonagin, who received his Purple Heart medal upon his death. Lonaginâs son, local resident Rick Morgan, presented that medal to Roscoe Smithâs brother, Jack Smith, at the town celebration Saturday, June 26 â 77 years to the day after his death. Morgan said he felt compelled to reunite the medal with Smithâs family after he discovered it locked inside a safety deposit box. He reached out to Mayor Russell Amos, who, after tracking down members of the Smith family, suggested he make the presentation at the celebration so the town could be a part of it. ....