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The virus SARS-CoV-2, which causes COVID-19.
Sanford Burnham Prebys Medical Discovery Institute
Senior study author Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys.
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Newswise LA JOLLA, CALIF. – Jan 12, 2020 – Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it’s time to mount an antiviral response. The study, published today in
Cell Reports, provides insights into the molecular basis of severe disease and may enable new strategies for the treatment and prevention of COVID-19. 
“Our research has shown that MDA-5 is the immune cop that’s tasked to keep an eye out for SARS-CoV-2 and call for back-up,” says Sumit Chanda, Ph.D., director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and senior author of the study. “MDA-5 recognizes replicating viruses in ....

Yuan Pu , Shimpei Gotoh , Dinah Ruch , Lisa Miorin , Laura Riva , Kristina Herbert , Adolfo Garcia Sastre , Juddf Hultquist , Chih Cheng Yang , Kouji Sakai , Adolfo Garcia Satre , Miyuki Yamamoto , Laura Martin Sancho , Jun Kanamune , Sanford Burnham Prebys , Sumit Chanda , Susan James Blair , Kyoto University , World Health Organization , Cancer Center , Northwestern University Feinberg School Of Medicine , Sanford Burnham Prebys Medical Discovery Institute , National Institute Of Infectious Diseases Tokyo , Icahn School Of Medicine At Mount Sinai , Pathogenesis Program At Sanford Burnham Prebys , Defense Advanced Research Projects Agency ,