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Zachary Ellison On May 1, 2021, Zachary Quinn Ellison passed away of natural causes in his sleep at his home in San Diego, Calif. Zach, or “Zinger,” was born on August 9, 1994, in Burlington to Annemarie Savage and Jeffrey Ellison. The youngest of four boys, Zach was the beloved baby brother a role he relished. As a child and teenager, Zach was a goofy prankster with a head of blond curly hair who kept his family and friends laughing. He graduated from Mount Abraham Union High School and went on to obtain a BS in architectural engineering from Vermont Technical College. After graduation, he moved to California for a job at a geotechnical engineering firm. His colleagues described him as a hardworking, kind, and witty person who led by example. ....
E-Mail Credit: Elsevier Philadelphia, January 26, 2021 - Addiction, or substance use disorder (SUD), is a complex neurological condition that includes drug-seeking behavior among other cognitive, emotional and behavioral features. Synaptic plasticity, or changes in the way neurons communicate with one another, drives these addictive behaviors. These lasting brain changes are at the crux of why addiction is so hard to treat. Biological Psychiatry, published by Elsevier, now shows that players in the extracellular environment - not just at neuronal interfaces - contribute to addiction plasticity. Neurons in a brain area called the nucleus accumbens are known to undergo addiction-related plasticity. Specifically, changes at synapses of medium spiny neurons (MSN), which sense the neurotransmitter dopamine, have been associated with drug-seeking and extinction behaviors. ....